Phytoestrogens, alcohol, and endometrial cancer risk

描述(由申请者提供)：这是一份学术生涯奖申请书，旨在支持罗格斯大学营养科学系副研究科学家elisa V.Bandera博士的培训和研究计划。该计划的目标是：1)通过提供营养学、营养流行病学、分子流行病学和癌症流行病学的坚实理论基础，补充她之前在医学和流行病学方面的培训；以及2)将这一理论培训应用于子宫内膜癌的病例对照研究。拟议的教育计划包括指导、结构化课程、研讨会、会议和指导性阅读。相关领域的高素质专家团队将通过这些活动指导应聘者，并帮助她实现目标。本申请中提出的研究建立在一项为期五年的以人群为基础的病例对照研究(Sara Oison博士，Pi；R01CA83918)的基础上，资助开始日期为2001年7月1日。为这项研究提供背景的病例对照研究包括600例子宫内膜样瘤、200例浆液性或透明细胞瘤和600例对照。这些病例将是21岁以上的妇女，新泽西州六个县的居民，患有新诊断的组织学确诊的上皮性子宫内膜癌。控制将与病例(+5岁)的频率匹配，并通过随机数字拨号(对于65岁以下的人)或从HCFA文件中选择(对于65岁以上的人)。拟议的项目扩大了父母资助的目标，其主要目标是评估雌激素、遗传学和膳食脂肪的作用。这项拟议项目的具体目的是调查植物雌激素和酒精消费与子宫内膜癌风险之间的关系。对体重指数、雌激素替代疗法、脂肪和总能量摄入量、吸烟、参与雌激素代谢的酶的基因型和组织学类型的可能影响进行研究。酒精和植物雌激素摄入量之间的相互作用也将被研究。拟议研究的另一个组成部分是在子宫内膜癌病例对照研究的背景下，评估一种创新的多媒体网络饮食评估方法--计算机辅助自访饮食历史--的可行性研究。这一奖项将为候选人提供在癌症营养流行病学领域发展独立事业所需的支持和培训。

DESCRIPTION (provided by applicant): This is an Academic Career Award application to support a training and research program for Dr. Elisa V. Bandera, an Associate Research Scientist in the Department of Nutritional Sciences, Rutgers University. The goals of this program are: 1) to complement her previous training in medicine and epidemiology by providing a strong theoretical foundation in nutrition, nutritional epidemiology, molecular epidemiology, and cancer epidemiology; and, 2) to apply this theoretical training in a case-control study of endometrial cancer. The proposed educational plan includes mentoring, structured courses, seminars, conferences, and guided readings. A highly qualified team of experts in the relevant areas will mentor the candidate through these activities and help her achieve her goals. The research proposed in this application builds upon a five-year population-based case-control study (Dr. Sara OIson, PI; R01CA83918), with a funding start date of July 1, 2001. The case-control study that provides the context for the proposed research includes 600 cases with endometrioid tumors, 200 with serous or clear cell tumors, and 600 controls. The cases will be women older than 21 years, residents of six counties in New Jersey, with newly diagnosed, histologically confirmed epithelial endometrial cancer. The controls will be frequency matched to the cases (+5years) and selected by random digit dialing (for those under 65) or from HCFA files (for those older than 65 years). The proposed project expands the objectives of the parent grant, whose main goals are to evaluate the role of estrogens, genetics, and dietary fat. The specific aims of the proposed project are to investigate the association between phytoestrogen and alcohol consumption and endometrial cancer risk. Possible effect modification by body mass index, estrogen replacement therapy, fat and total energy intake, smoking, genotypes for enzymes involved in estrogen metabolism, and histologic type will be investigated. Interactions between alcohol and phytoestrogen intakes will also be examined. An additional component of the proposed research is a feasibility study to evaluate an innovative multi-media web-based dietary assessment method, the Computer-Assisted Self-Interview Diet History, in the context of the case-control study of endometrial cancer. This award will provide the support and training the Candidate needs to develop an independent career in the nutritional epidemiology of cancer.