Washington University Molecular Imaging Center

描述(由申请人提供)： 华盛顿大学医学院的活体细胞和 分子成像中心(ICMIC)设想了一种允许 中心将成为体内小说发展的焦点 在校园里开展分子成像活动。这涉及到进一步扩大和 加强协作，提高多学科的工作效率 基础癌细胞生物学和分子成像研究项目。这个 拟议的P50计划的最终目标是将机构 华盛顿大学在分子基础科学方面的专业知识 肿瘤学、免疫学、分子遗传学和信号转导 在正式配置下开发的医学成像基础设施 一个ICMIC。我们处于战略地位，专注于我们ICMIC的大部分业务 关于新的互动和协作肿瘤学进展的资源 分子成像项目。为了实现这些目标，一个组织结构 拥有三个分子成像核心，四个多学科ICMIC研究 项目、四个发展研究项目、一个教育方案和一个 提出了培训/职业发展计划。这四个项目， 在校园中代表创新和令人兴奋的新举措的有：1) 前列腺癌基因表达的活体成像，2)非侵袭性 监测T细胞介导的肿瘤消融，3)肿瘤病毒成像 TAT转导多肽，4)MDRI P-糖蛋白转运活性成像 活体~(94)m-Sestamibi PET预测肺癌化疗疗效的研究 广泛期小细胞肺癌。一个企业的组织结构 ICMIC已经建立，并通过我们的Active P20实现了所有里程碑 规划拨款。P50中心拨款现在将促进在分子方面的卓越表现 通过为跨学科提供一种正式的渠道，在癌症研究中进行成像 多模式协作。

DESCRIPTION (provided by applicant): Washington University Medical School's concept of an In Vivo Cellular and Molecular Imaging Center (ICMIC) envisions a process that will permit the Center to become the focal point for the development of novel in vivo molecular imaging initiatives on campus. This involves further expanding and reinforcing collaborations and enhancing the productivity of multidisciplinary programs in basic cancer cell biology and molecular imaging research. The ultimate objective of the proposed P50 Program is to combine the institutional expertise of Washington University in the basic sciences of molecular oncology, immunology, molecular genetics and signal transduction with our well developed infrastructure in medical imaging under the formal configuration of an ICMIC. We are strategically positioned to focus the majority of our ICMIC resources on the advancement of novel interactive and collaborative oncologic molecular imaging projects. To meet these goals, an organizational structure with three molecular imaging cores, four multidisciplinary ICMIC research projects, four developmental research projects, an educational program and a training/career development program are proposed. The four projects, representing innovative and exciting new initiatives on campus are: 1) In Vivo Imaging of Gene Expression in Prostate Cancer, 2) Non-Invasive Monitoring of T Cell-Mediated Tumor Ablation, 3) Imaging Cancer Viruses with Tat Transducible Peptides, 4) Imaging MDRI P-glycoprotein Transport Activity In Vivo with Tc-94m-Sestamibi PET to Predict Response to Chemotherapy in Extensive Stage Small Cell Lung Cancer. An organizational structure for an ICMIC has been established and all milestones achieved with our active P20 planning grant. The P50 Center grant will now promote excellence in molecular imaging in cancer research by providing a formal conduit for interdisciplinary multi-modality collaborations.