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Immediate Hypersensitivity Responses--control In Parasit

Immediate Hypersensitivity Responses--control In Parasit
立即超敏反应——寄生虫的控制
批准号：
6986439
负责人：
THOMAS B NUTMAN
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6986439
关键词：
cytokineenzyme linked immunosorbent assayeosinophiliafilariasisflow cytometryhuman subjectimmediate hypersensitivityimmunoglobulin Einflammationlaboratory mousenucleic acid sequenceparasitic diseasespolymerase chain reactiontissue /cell culture

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中文摘要
翻译
嗜酸性粒细胞增多症已被广泛研究，我们已经确定了区分嗜酸性粒细胞增多症的骨髓增生性和淋巴增生性的新标记物。有了这个区别，我们制定了新的治疗方法（伊马替尼，抗il - 5）来治疗这些形式。利用流行病学工具，结合变态反应性疾病的生理测量和免疫学评估，研究了寄生虫感染与变态反应性疾病之间的相互作用。我们已经证明，慢性蠕虫感染可以预防过敏性疾病。
英文摘要
Hypereosinophilic conditions have been studied extensively, and we have identified new markers that distinguish between a myeloproliferative and a lymphoproliferative form of the Hyperosinophilic Syndrome. Having made this distinction, we have instituted new therapies (imatinib, anti-IL5) for the treatment of each of these forms. The interaction between helminth infeciton and allergic disease has been studied using epidemiological tools coupled with physiological measurements of allergic disease and immunological assessments. We have demonstrated that chronic helminth infection protects against allergic diseases.
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会议论文
CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
CLINICAL AND THERAPEUTIC STUDIES OF HUMAN FILARIASIS
Clinical And Therapeutic Studies Of Human Filariasis
MOLECULAR DEFINITION OF FILARIAL AND RELATED NONFILARIAL GENES AND PROTEINS
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