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Design Of Immunogens

Design Of Immunogens
免疫原的设计
批准号：
6987285
负责人：
Peter D Kwong
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/6987285
关键词：
AIDS vaccinesCD4 moleculeHIV envelope proteinHIV envelope protein gp120SDS polyacrylamide gel electrophoresisX ray crystallographyantigen antibody reactionantigensbiomimeticsbiotechnologycalorimetryconformationhuman immunodeficiency virus 1human tissueneutralizing antibodyphysical modelprotein engineeringprotein foldingreceptor bindingsite directed mutagenesistissue /cell culturetransfectionvaccine developmentvirus receptors

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中文摘要
翻译
鉴于我们对基于包膜的体液逃避机制的理解，我们试图设计基于包膜的免疫原，使这些机制失效。这种防御能力减弱的免疫原可能会引起更广泛的中和抗体。
英文摘要
Given our understanding of envelope-based mechanisms of humoral evasion, we have attempted to design envelope-based immunogens with these mechanisms disabled. Such modied immunogens with weakened defenses may elicit more broadly neutralizing antibodies.
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会议论文
CAPRISA HIV-1 neutralizing antibodies: Harnessing ontogeny for immunogen design
Mechanisms Of Humoral Evasion
Computational Tools for Protein Crystallization and Structural Analysis
Design of Antigenically-Specific Probes for Sera Analysis and MAb Isolation
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