How does host cell influence HIV diversification?

艾滋病毒是一种快速进化的病毒，在感染者体内，它不断获得新的突变，并通过重组将突变连接在一起。我们开发了一种研究重组的新系统，并发现不同的个体具有不同的重组率，这可能有助于解释为什么一些个体活得更长。这个项目旨在确定导致不同重组率的机制，以及我们如何改变这些机制来改善患者的预后。

HIV is a rapidly evolving virus, and within an infected individual it continually acquires new mutations and joins together mutations by recombination. We have developed a novel system for studying recombination, and find that different individuals have different recombination rates, which may contribute to why some individuals survive longer. This project aims to identify the mechanisms responsible for differing recombination rates and how we can alter these to improve patient outcome.