NCRR - High end instrumentation (HEI)

描述(由申请人提供)：临床流行病学和生物统计中心(CCEB)与宾夕法尼亚大学医学院(UPenn SOM)的艾布拉姆森癌症中心和人类研究办公室(OHR)一起，正在申请一个专门的研究计算基础设施，以支持NIH资助的许多有价值的项目。该方案要求SUN SUNFIRE 12K高端数据中心服务器，支持大规模数据库和统计计算。这些设备将取代严重不足的甲骨文(Oracle)数据库和统计计算基础设施，提供新的计算性能、容量和可靠性。这项提案需要甲骨文临床(R)，这是一种专门的软件，将允许集中管理临床方案、科学数据、法规遵从性和质量保证的新功能。我们提出这些具体目标是为了确保继续支持NIH项目：1)替换过时的数据库环境，2)替换不充分的统计计算环境，3)提供扩展的计算性能、容量和新能力，以便可以对当前/未来的NIH项目提供集中支持。作为支持，CCEB、艾布拉姆森癌症中心和OHR提出了可能由该设备维持的选定的NIH项目。CCEB项目(30个N1H项目，总成本为1.9亿美元)范围从统计方法R01、临床研究R01和P01项目，到数据协调中心(DCC)和教育与研究治疗中心(CERT)的合作协议(U01、U10、U18)。艾布拉姆森癌症中心是NCI指定的综合性癌症中心，有449个由NIH资助的项目(全年总成本为1.3亿美元)。这包括19个P01，3个P50，15个合作U型奖项，以及大量的临床试验。OHR负责在SOM内进行的所有临床研究(346个NIH项目，总成本为3.27亿美元)的法规遵从性。临床研究计算单元(CRCU)是SOM的核心研究机构，提供大规模临床研究和统计方法拨款所需的计算基础设施。NIH的这些项目需要先进的数据库技术，例如部署在WWW上的远程数据输入和管理。这些项目涉及广泛的统计分析，进一步增加了对计算基础设施的需求。CRCU提供和维护为Oracle(R)数据库管理系统、SAS(R)、S+(R)和STATA(R)配置的设备；然而，扩展的NIH研究已经超过了1997年安装的服务器的性能、容量、可靠性和能力限制。每个新资助的NIH项目都进一步强调了计算基础设施，而没有增加集中管理试验的新能力。这一专门的计算设备申请符合NCRR的目标，即在多笔赠款中提供共享资源，这些赠款成本过高，难以证明个别项目的合理性。

DESCRIPTION (provided by applicant): The Center for Clinical Epidemiology and Biostatistics (CCEB), together with the Abramson Cancer Center and Office of Human Research (OHR), at the University of Pennsylvania School of Medicine (UPENN SOM) is requesting a specialized research computing infrastructure in support of numerous, meritorious NIH-funded projects. This proposal requests a SUN SunFire 12K High-End Data Center Server, in support of large-scale database and statistical computing. The equipment will replace a seriously inadequate Oracle (r)database and statistical computing infrastructure, providing new computing performance, capacity and reliability. This proposal requests Oracle Clinical (r), specialized software that will permit a new capability for centralized management of clinical protocols, scientific data, regulatory compliance, and quality assurance. We propose these specific aims to ensure continued support of NIH projects: 1) replace an obsolete database environment, 2) replace an inadequate statistical computing environment, and 3) provide expanded computing performance, capacity, and new capability, so that current/future NIH projects can be centrally supported. In support, CCEB, the Abramson Cancer Center, and OHR present selected NIH projects potentially sustained by this equipment. CCEB projects (30 N1H projects with total costs, all years of $190M) range from statistical methodology R01s, to clinical research R01 and P01 projects, to cooperative agreements (U01,U10,U18) for Data Coordinating Centers (DCCs), and Centers for Education and Research Therapeutics (CERTs). The Abramson Cancer Center, an NCI- designated comprehensive Cancer Center, has 449 NIH funded projects ($130M total costs, all years.) This includes 19 P01s, 3 P50s, 15 cooperative U-type awards, and a vast array of clinical trials. OHR is responsible for the regulatory compliance of all clinical research (346 NIH projects with total costs, all years of $327M) conducted within the SOM. The Clinical Research Computing Unit (CRCU), a SOM Core Research Facility, provides the computing infrastructure required by large-scale clinical research and statistical methodology grants. These NIH projects require advanced database technologies, such as WWW-deployed remote data entry and management. These projects involve extensive statistical analysis, further increasing computing infrastructure needs. The CRCU provides and maintains equipment configured for the Oracle (r) Database Management System, SAS (r), S-PLUS (r), and STATA(r); however, expanding NIH research has exceeded the performance, capacity, dependability, and capability limits of the servers installed in 1997. Each newly funded NIH project further stresses the computing infrastructure, without adding new capabilities for centrally managing trials. This specialized computing equipment request meets the NCRR goals of providing shared resources across multiple grants that are cost-prohibitive and difficult to justify for individual projects.