C-H Alkylation with Alcohols: Dual Catalytic C-H Alkylation using Alcohols as Electrophiles by Carbocation Promoted Oxidative Addition

本研究将以醇为烷基化试剂，开发钯催化碳氢键的烷基化反应。碳氢化合物功能化在复杂分子的构建中具有显著的优势，避免了预功能化。迄今为止，碳氢化合物烷基化的发展程度低于其他碳氢化合物功能化过程，通常依赖于有毒的烷基卤化物。本文将开发一种以醇类为烷基化剂的双催化系统。这项工作将扩大目前有限的C-H烷基化反应范围，并避免对活化的烷基卤化物的要求。反应开发（命中查找）和优化（DOE）将在自动化（ROAR中的Freeslate平台）的帮助下进行，以快速确定反应空间。然后将详细研究成功的反应，以获得进一步的见解。该项目由阿斯利康共同资助并与阿斯利康合作，并可能包括进行安置的可能性。

This research will develop the palladium-catalysed alkylation of C-H bonds using alcohols as the alkylating reagent. C-H functionalisation promises significant advantages in the construction of complex molecules avoiding pre-functionalisation. To date, C-H alkylation is less developed than other C-H functionalisation processes, and commonly relies on toxic alkyl halides. Here, a dual catalytic system will be developed to employ alcohols as alkylating agents. This work will expand the currently limited scope of C-H alkylation reactions, and avoid the requirement for activated alkyl halides. Reaction development (hit finding) and optimisation (DOE) will be performed with the aid of automation (Freeslate platforms in ROAR), to rapidly scope out the reaction space. Successful reactions will then be studied in detail for further insights. This project is co-funded by and in collaboration with AstraZeneca, and may include the possibility to undertake a placement.