CLINICAL CORE

临床核心负责维持一个特征良好的研究对象库，以支持正常衰老、阿尔茨海默病（AD）、血管性痴呆（VD）和其他痴呆症的研究。它也是获得尸检许可、成像数据和阿尔茨海默病中心统一数据集的重要资源。药理学课程是临床核心的一个组成部分。最后，临床核心作为EIT核心临床医生的培训场所。临床核心的具体目标是：1)招募、评估和诊断由AD和VD引起的轻度认知障碍和痴呆的多种族受试者，以及正常的老年b对照组；la)招募受试者并转介到药理学项目进行临床试验；lb)将特征良好的受试者转介到项目#1 (M Singh， PI)；lc)维护研究课题注册表（“库”），以支持其他ADRC附属研究项目；2)对正常衰老、轻度认知障碍（MCI）和AD痴呆受试者进行重复临床评价和神经心理测试（纵向研究）；3) Coordinatio_

The Clinical Core is responsible for maintaining a well-characterized pool of research subjects to support researcl in normal aging, Alzheimer disease (AD), vascular dementia (VD), and other dementias. It is also an essential resourc for obtaining autopsy consent, imaging data, and the Alzheimer Disease Center uniform data set. The Pharmacology Program is an integral component of the Clinical Core. Finally, the Clinical core serves as a training site for clinicians in the EIT core. The specific aims of the Clinical Core are: 1) Recruitment, evaluation, and diagnosis of ethnically-diverse subjects with mild cognitive impairment and dementia due to AD and VD, as well as normal elder b controls; la)Recruitment of subjects and referral to Pharmacology Program for clinical trials; lb) Referral of well-characterized subjects to Project #1 (M Singh, PI); lc) Maintenance of a research-subject registry ("pool") to support other ADRC affiliated research projects; 2) Repeat clinical evaluation and neuropsychological testing for subjects with normal aging, mild cognitive impairment (MCI) and AD dementia (Longitudinal Study); 3) Coordinatio_ of clinical components (with Pathology Core) of the Autopsy and Biological Tissue Program, including obtaining informed consent for autopsy, maintaining relevant clinical data, obtaining blood samples for apoE genotyping; 4) Coordination of the clinical components (with the Imaging Core) of an MRI Archive; 5) Submission of clinical data (with Data Management Core) to the National Alzheimer Coordinating Center (NACC). Clinical activities directed toward English-speaking subjects are described in the Clinical Core, while those for Spanish-speaking subjects are described in the Spanish Speaking Satellite (SSS).