SUPERFUND CHEMICALS: TRANSPORT, METABOLISM & TOXICITY

肯塔基大学的超级基金基础研究项目是由24名教职员工共同努力的，他们代表了肯塔基大学和其他两个机构的17个学术单位。代表肯塔基大学和其他两个机构的17个学术单位的总体重点。我们计划的总体重点是调查多氯联苯和相关卤代化合物对健康不利影响的机制；为这些环境污染物开发高度敏感和特异的传感系统，以开发暴露在高度暴露的人类人口中的暴露和毒性生物标志物；并探索这些卤化物的先进补救技术和销毁方法。我们的计划有可能提出针对多氯联苯引发的疾病的营养干预措施，如动脉粥样硬化和癌症，这些都是肯塔基州的关键问题，肯塔基州拥有许多超级基金站点，地下水和地表水普遍受到污染。提交了七个项目，以支持我们重点研究地下水和地表水的污染问题。提交以支持我们重点研究的七个项目包括：与健康有关的项目，调查卤代烃在致癌过程中引发、促进和促进转移的机制(项目#1、#3和#7)以及作为内皮细胞和内分泌功能干扰物的项目(项目#2和#4)；以及涉及利用重组系统检测超级基金化学品的环境项目(项目#4)、利用重组系统对超级基金化学品进行销毁和修复技术(项目#4)以及销毁和修复技术(项目#5)。这些研究项目得到四个核心的支持：行政(A)、综合(B)、外联(C)和培训(D)。项目管理将帮助协调、信息传输、实验设计和分析以及研究评估。评估过程在外部咨询委员会的年度会议上达到高潮，在会上对每个项目进行审查并提出建议。合成核心负责合成所有要研究的化合物。外展中心将把研究成果传递给在超级基金网站附近肝脏的肯塔基州人。培训核心和研究项目提供了12名博士生的培训。总体而言，这一多学科计划旨在将广泛的经验和经验应用于与超级基金化学品相关的问题，这些问题对肯塔基州联邦和国家至关重要。

The Superfund Basic Research Program at the University of Kentucky is the joint effort of 24 faculty, representing 17 academic units at the University of Kentucky and two other institutions. The overall focus of representing 17 academic units at the University of Kentucky and two other institutions. The overall focus of our Program is to investigate the mechanisms of the adverse health effects of PCBs and related halogenated compounds; to develop highly sensitive and specific sensing systems for these environmental pollutants to develop biomarkers of exposure and toxicity in a highly-exposed human population; and to explore advanced remediation techniques and methods of destruction of these halogenated compounds. Our Program has the potential to propose nutritional interventions against PCB-mediated diseases, such as atherosclerosis and cancer, critical issues in the state of Kentucky, which has numerous Superfund sites and widespread contamination of ground and surface waters. Seven projects, submitted to support our focused research, contamination of ground and surface waters. Seven projects, submitted to support our focused research include health-related projects that investigate mechanisms of halogenated hydrocarbons has initiating, promoting, and metastasis-enhancing agents in carcinogenesis (Projects #1, #3, and #7) and as disruptors of endothelial cell and endocrine function (Projects #2 and #4); and environmental projects involving the sensing of Superfund Chemicals with recombinant systems (Project #4), and destruction and remediation technologies of Superfund Chemicals with recombinant systems (Project #4), and destruction and remediation technologies (Project #5). These research projects are supported by four Cores: Administration (A); Synthesis (B); Outreach (C); and Training (D). Project administration will aid in coordination, information transfer, design and analysis of experiments, and assessment of research. The assessment process culminates in an annual meeting of the External Advisory Committee, where each project is reviewed and recommendations made. The synthesis core is responsible for synthesizing all compounds to be studied. The outreach core will transmit research findings to Kentuckians who liver near Superfund sites. The training core and the research projects provide for the training of >12 doctoral students. Overall this multi-disciplinary Program is designed to bring a broad range of experience and experience to bear on problems associated with Superfund chemicals, critical to the Commonwealth of Kentucky and the nation.