Extinguishing the fire: inflammasome inhibition
Extinguishing the fire: inflammasome inhibition
批准号:
nhmrc : 1141131
负责人:
A/Pr Kate Schroder
金额:
$32.23万
依托单位国家:
澳大利亚
项目类别:
Career Development Fellowships
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2021-12-31
中文摘要
在受伤或感染期间,我们身体的免疫系统通过引发炎症来保护我们。但不受控制的炎症会导致癌症、糖尿病、阿尔茨海默氏症和帕金森氏症等常见疾病。这项研究计划将揭示人体如何使炎症体失活--炎症和疾病的核心蛋白质复合体--这样我们就可以设计出更好的药物来治疗炎症驱动的疾病患者。
英文摘要
During injury or infection, our body’s immune system protects us by launching inflammation. But uncontrolled inflammation drives common diseases such as cancer, diabetes, Alzheimer’s and Parkinson's. This research program will reveal how the body deactivates inflammasomes – protein complexes at the heart of inflammation and disease – so we can design better drugs for treating patients with inflammation-driven disease.
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会议论文
Extinguishing the fire: inflammasome inhibition
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批准号:nhmrc : GNT1141131
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项目类别:Career Development Fellowships
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资助金额:$47.67万
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财政年份:2018
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负责人:A/Pr Kate Schroder
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依托单位:
Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors
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批准号:nhmrc : GNT1129208
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项目类别:Project Grants
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资助金额:$57.29万
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财政年份:2017
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负责人:A/Pr Kate Schroder
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依托单位:
A novel mechanism for IL-1β secretion
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批准号:nhmrc : GNT1122240
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项目类别:Project Grants
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资助金额:$60.82万
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财政年份:2017
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负责人:A/Pr Kate Schroder
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依托单位:
A novel mechanism for IL-1? secretion
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批准号:nhmrc : 1122240
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项目类别:Project Grants
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资助金额:$41.51万
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财政年份:2017
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负责人:A/Pr Kate Schroder
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依托单位:
Inflammatory pathways to liver fibrosis in non-alcoholic and alcoholic steatohepatitis: reversal by NLRP3 inhibitors
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批准号:nhmrc : 1129208
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项目类别:Project Grants
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资助金额:$39.08万
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财政年份:2017
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负责人:A/Pr Kate Schroder
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依托单位:
Autophagic suppression of ASC inflammasomes
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批准号:nhmrc : 1106217
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项目类别:Project Grants
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资助金额:$38.17万
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财政年份:2016
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负责人:A/Pr Kate Schroder
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依托单位:
Autophagic suppression of ASC inflammasomes
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批准号:nhmrc : GNT1106217
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项目类别:Project Grants
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资助金额:$55.7万
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财政年份:2016
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负责人:A/Pr Kate Schroder
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依托单位:
Inhibitors of NLRP3 activation for treatment of inflammatory CNS diseases
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批准号:nhmrc : 1086786
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项目类别:Project Grants
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资助金额:$68.22万
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财政年份:2015
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负责人:A/Pr Kate Schroder
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依托单位:
Microbial evasion of a novel inflammasome by Salmonella
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批准号:nhmrc : 1064945
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项目类别:Project Grants
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资助金额:$32.42万
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财政年份:2014
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负责人:A/Pr Kate Schroder
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依托单位:
Caspase 8 apoptotic signalling induced by the inflammasome
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批准号:nhmrc : 1050651
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项目类别:Project Grants
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资助金额:$40.22万
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财政年份:2013
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负责人:A/Pr Kate Schroder
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依托单位:
Inflammasome function in neutrophils
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批准号:nhmrc : 1023297
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项目类别:Project Grants
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资助金额:$22.51万
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财政年份:2012
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负责人:A/Pr Kate Schroder
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依托单位:
Inflammasome function in gastrointestinal immunity and inflammation
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批准号:nhmrc : 490993
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项目类别:Early Career Fellowships
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资助金额:$28.08万
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财政年份:2008
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负责人:A/Pr Kate Schroder
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依托单位:
海外基金