Extracellular cues compete with TCR signalling to alter lymphocyte polarity, fate and function.

在感染后，我们的免疫系统产生大量不同的细胞库，这些细胞需要安装和调节适当的免疫反应。控制不同类型免疫细胞发育的信号，以及细菌和病毒如何影响免疫细胞发育，目前还没有完全了解。该项目将研究免疫细胞发育的调控，以及来自感染因子的竞争信号如何影响这一过程。

Following an infection, our immune system generates a large and diverse repertoire of cells required to mount and regulate an appropriate immune response. The signals that control the different types of immune cells that develop, and how bacteria and viruses influence immune cell development, are not fully understood. This project will investigate the regulation of immune cell development, and how competing signals from infectious agents influence this process.