Re-Engineering the Clinical Research Enterprise

我们建议发展协调临床研究网络(CCSN)，这是一个无与伦比的临床和卫生服务研究机构，建立在HMO研究网络(HMORN)现有能力的基础上。HMORN成员计划在美国每个地区提供从预防到缓解的全面服务，范围从预防到缓解，到1300万人或美国人口的4%。在本合同的三年期限内，我们将围绕内部和外部沟通展开一系列任务的竞争；减少临床研究中多地点合作的科学、行政和经济障碍；建立通用的IRB、患者留存和招募以及临床研究程序，并创建标准的项目结束程序。我们将为CCSN建立以网络为基础的业务，支持所有通信努力以及共同的数据收集和分析协议，由CCSN生物统计和经济分析核心提供便利。

We propose to develop the Coordinated Clinical Studies Network (CCSN), an unparalleled research facility for clinical and health services research that builds on the current capacity of the HMO Research Network (HMORN). HMORN member plans provide comprehensive services in every US region ranging from prevention to palliation, to a defined population of 13 million people or 4% of the US population. During the three-year duration of this contract we will compete a series of tasks around internal and external communication; reducing scientific, administrative and economic barriers to multi-site collaboration in clinical studies; build common IRB, patient retention and recruitment and clinical studies procedures and create standard project closeout procedures. We will establish web-based operations for the CCSN that will support all communication efforts as well as common data collection and analysis protocols, facilitated by the CCSN biostatistics and economics analytic cores.