CORE--CLINICAL ASSESSMENT CORE

拟议的临床评估核心代表了我们过去九年研究方法的演变，并将继续开展参与者随访，评估和诊断项目的重要方面。在我们对WHICAP II队列的随访中，我们将保持病例识别方法的一致性和连贯性。在流行病学、数据库管理和统计核心生成的跟踪表格的指导下， 每12-18个月进行一次标准化的联系、面谈和检查。所有科目的管理措施，评估个人自我维护活动，知觉困难的记忆，和流动性。 综合神经心理学测试包括记忆、语言、执行功能、视觉空间技能和定向的测量。神经心理学数据通过原始的和人口统计学校正的个人测试分数以及代表记忆、执行功能和语言的神经心理学因素分数提供给项目 能力.所有参与者都接受医学/精神病学评估和独立于神经心理学测试表现的功能能力评估。具有中风或帕金森病史的参与者或具有痴呆的功能或神经心理学体征的参与者将接受委员会认证的神经科医生的评估。 所有参与者的信息在神经心理学家，研究医生和神经学家的诊断共识会议上进行审查，并根据标准化的诊断标准得出诊断。重点是在整个研究期间这些标准的一致性。临床中心将与脑成像中心协调，安排合格受试者进行MRI扫描。临床评估核心还与病理学分子核心协调，以接近所有参与者的大脑捐赠，获得临时同意，并在死亡时进行尸检。

The proposed Clinical Assessment Core represents an evolution of methods from our past nine years of studies and will continue to carry out essential aspects of participant follow-up, assessment, and diagnosis for the projects. In our follow-up of the WHICAP II cohort, we will maintain uniformity and coherence in our approach to case identification. Guided by a tracking form generated by the Epidemiology, Database Management and Statistics Core, participants are contacted, interviewed and examined in a standardized fashion every 12-18 months. All subjects are administered measures assessing personal self-maintenance activities, perceived difficulty with memory, and mobility. Comprehensive neuropsychological testing includes measures of memory, language, executive functioning, visuospatial skill, and orientation. Neuropsychological data are available to the projects through raw and demographically corrected individual tests scores, and Neuropsychological Factor Scores representing memory, executive function, and language abilities. All participants receive a medical/psychiatric evaluation and an assessment of functional capacity that is independent of neuropsychological test performance. Participants with history of stroke or Parkinson's disease or those with functional or neuropsychoiogical signs of dementia will receive an evaluation by a board-certified neurologist. Information for all participants is reviewed at a diagnostic consensus conference of neuropsychologists, research physicians, and neurologists, and diagnoses are derived based on standardized diagnostic criteria. Emphasis has been placed on the consistency of these criteria over the entire study period. The clinical core will coordinate with the Brain Imaging Core to schedule eligible participants for MRI scans. The Clinical Assessment Core also coordinates with the Pathology Molecular Core to approach all participants about brain donation, obtain provisional consent, and obtain autopsies at the time of death.