A MultiDisciplinary Cancer Research Facility at Purdue University

描述（由申请人提供）：NCRR ARRA C06项目提供了在普渡大学建立疾病研究重点实验室设施的机会。拟议中的“多学科癌症研究设施”（MCRF）将把普渡大学癌症研究中心（CCR）来自不同部门和学科的研究人员共同安置在一起，进行跨学科的合作研究，这些研究将建立创新动物疾病模型、开发新疗法和体内动物成像的能力——这是普渡大学疾病研究人员的一个关键未满足的需求。该设施将包括一个现代化的动物成像套件，可容纳9.4特斯拉40厘米口径磁共振成像仪、单光子发射计算机断层扫描/计算机断层扫描（SPECT/CT）和多模态（包括荧光和x射线）全动物成像系统；所有这些都在拟议的设施中具有屏障功能，也将容纳成功的CCR转基因小鼠生产操作。MCRF是普渡大学多学科研究中心探索公园（DP）宾德利生物科学中心（BBC）的一个约29,000总平方英尺的扩建项目。MCRF设施研究将为BBC在生物物理和生物分子分析、传统细胞成像和分离以及高通量筛选技术方面建立的能力提供补充，并将从中受益。此外，MCRF将与Birck纳米技术中心建立纳米医学能力联系。MCRF的实验室将采用DP共享空间政策，并将按功能组织，同时为多个研究人员和项目服务。实验室计划用于癌症细胞生物学、治疗和医疗设备开发、基于细胞的筛选、药物化学和下一代成像。拟议中的建筑将以普渡大学在癌症研究、工程、化学和仪器仪表以及兽医学方面的优势为基础，建立一个以疾病研究为重点的多学科生物医学研究设施。多学科方法促进了癌症和其他疾病的研究进展，这些方法为更好地了解疾病以及更好地诊断和治疗带来了效率和创新。MCRF将扩展普渡大学在生物医学多学科研究方面的卓越成就。

DESCRIPTION (provided by applicant): The NCRR ARRA C06 program provides an opportunity to build a disease research focused laboratory facility at Purdue University. The proposed 'Multidisciplinary Cancer Research Facility' (MCRF) will co-locate Purdue Center for Cancer Research (CCR) investigators from diverse departments and disciplines for collaborative, transdisciplinary research that will build capabilities for generation of innovative animal models of disease, development of new therapeutics, and in vivo animal imaging - a critical unmet need for disease researchers at Purdue. The facility will include a modern animal imaging suite that will accommodate a 9.4 Tesla 40cm bore Magnetic Resonance Imager, Single Photon Emmission Computer Tomography/ Computer Tomography (SPECT/CT), and multimodal (including fluorescence and x-ray) whole animal imaging system; all in the proposed facility vivarium with barrier function that will also house the successful CCR transgenic mouse production operation. The MCRF is a proposed ~29,000 gross square feet addition to the Bindley Bioscience Center (BBC) in Purdue's hub for multidisciplinary research, Discovery Park (DP). MCRF facility research will provide a complement to, and will benefit from, established BBC capabilities in biophysical and biomolecular analyses, conventional cell imaging and separation, and high throughput screening technologies. In addition, the MCRF will connect with the Birck Nanotechnology Center for nanomedicine capabilities. Laboratories in the MCRF will adopt the DP shared space policy and will be organized by function to serve multiple investigators and projects simultaneously. Laboratories are planned for cancer cell biology, thereapeutic and medical device development, cell-based screening, medicinal chemistry, and next generation imaging. The proposed building addition will build on strengths at Purdue University in cancer research, engineering, chemistry and instrumentation, and veterinary medicine, with a disease research-focused, multidisciplinary facility for biomedical research. Research progress in cancer and other diseases is augmented by multidisciplinary approaches that bring efficiency and innovation to the search for better understanding of disease, as well as better diagnostics and therapeutics. The MCRF will extend Purdue's excellence in biomedical multidisciplinary research.