ASCB Summer Meeting: Nuclear Architecture and Disease

描述(申请人提供)：本次关于核结构和疾病的会议将由美国细胞生物学学会(ASCB)主办。会议议题由ASCB成员提出，并由一个委员会根据重要性、及时性、兴趣以及组织者和潜在演讲者的优势来选择。这次会议将于2005年7月21日至24日在爱荷华州艾姆斯的爱荷华州立大学举行。它将提供核结构的前沿概述，并探索核结构与人类疾病之间的新联系，包括衰老、心血管疾病、癌症、肌肉营养不良、糖尿病、皮肤、骨骼和神经疾病。这种形式将促进基础和临床研究人员之间的跨学科合作，并将由经验丰富的远见卓识者和新的研究人员进行演讲。预计这次会议将对核疾病机制产生新的见解，并确定未来的关键方向。以前没有就这一专题举行过一次全面会议，部分原因是不到5年前才发现板层和疾病之间的大多数联系，以及需要最近的技术进步来认识核内空间组织对人类基因组的影响。细胞生物界认为，召开一次关于核结构和疾病的全面会议是发展这一领域的当务之急，并刺激基础和临床研究中的许多相关领域。会议将包括6次主题演讲、关于染色体和基因活性、椎板和椎板病、核内网络和体系结构的会议，以及从摘要中精选的整个会议致力于前沿工作。超过40%的平台演讲将从摘要中挑选出来，主要以年轻调查人员为特色。将有海报会议来刺激一对一的互动。这种形式将对约200名观众具有教育意义和激动人心的作用，平均分配给受训人员和初级和高级调查人员。这次会议将促进激烈的非正式讨论，寻找共同的原则，并将激发人们对这一新兴的“后基因组”领域的兴趣和进展。

DESCRIPTION (provided by applicant): This meeting on Nuclear Architecture and Disease will be sponsored by the American Society for Cell Biology (ASCB). Meeting topics are proposed by ASCB members and selected by a committee based on significance, timeliness, interest and the strengths of the organizers and potential speakers. This meeting will be held at Iowa State University, Ames Iowa, on July 21-24 of 2005. It will provide a cutting-edge overview of nuclear architecture, and explore novel links between nuclear architecture and human diseases including aging, cardiovascular disease, cancer, muscular dystrophy, diabetes, skin, bone and nerve disorders. The format will stimulate interdisciplinary collaborations between basic and clinical researchers, and will feature talks both by experienced visionaries and new investigators. The meeting is expected to generate novel insights into nuclear disease mechanisms and identify key future directions. A comprehensive meeting on this topic has not previously been held, in part because most links between lamins and diseases were discovered less than 5 years ago, and because recent technical advances were required to appreciate the impact of intranuclear spatial organization on the human genome. A comprehensive meeting on nuclear architecture and disease is viewed by the cell biology community as urgent to develop this field and stimulate many related fields in basic and clinical research. The meeting will include 6 keynote talks, sessions on chromosomes and gene activity, lamins and laminopathies, intra-nuclear networks and architecture, and an entire session devoted to cutting-edge work selected from abstracts. Over 40% of the platform talks will be selected from abstracts and feature primarily young investigators. There will be poster sessions to stimulate one-on-one interactions. The format will be educational and exciting to an audience of ~200, evenly distributed between trainees and junior and senior investigators. The meeting will foster intense informal discussion in search of common principals and will stimulate interest and progress in this emerging 'post-genomic' field.