Conference Modeling of Protein Interactions in Genomes

描述(申请人提供)：请求支持将于2005年6月24-27日在堪萨斯州劳伦斯举行的2005年基因组中蛋白质相互作用的多学科建模会议。这次会议将涉及生物、物理和计算科学家，并将重点讨论重建和研究基因组中蛋白质之间连接网络的计算程序，包括实验研究、基于知识的方法、序列分析和结构方法。2005年基因组会议蛋白质相互作用模型的具体目标如下：(1)讨论蛋白质相互作用的结构方面，包括对接方法；(2)讨论使用基于序列和基于结构的方法确定蛋白质结合位点的当前和新兴方法；(3)基于各种实验技术(例如，质谱学、低温电子显微镜、交联法、核磁共振等)对蛋白质-蛋白质相互作用进行建模；以及(4)解决与大规模筛选实验(主要是双杂交论文和质谱学)的蛋白质相互作用网络分析相关的计算问题。 来自蛋白质相互作用各个领域的专家被选为我们咨询委员会的成员，并出席了会议。咨询委员会将邀请并从提交的摘要中挑选出进一步的专题介绍。其中一个会议日将举行招贴会。会议规模相对较小，约有100人参加。主办方将特别注意吸引年轻的调查人员作为演讲者和海报主持人。我们将鼓励学生和博士后参与。会议组织的一个重要方面将是我们努力通过吸引妇女和少数族裔科学家使参与多样化。这将主要通过联系少数族裔服务机构中生物物理和生物化学领域的教员来实现。

DESCRIPTION (provided by applicant): Support is requested for the multidisciplinary conference MODELING OF PROTEIN INTERACTIONS IN GENOMES 2005, to be held on 24-27 June, 2005 in Lawrence, Kansas. The meeting will involve a combination of biological, physical, and computational scientists, and will focus on computational procedures for reconstruction and study of the networks of connections between proteins in genomes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches. The specific aims of the Modeling of Protein Interactions in Genomes Conference 2005 are as follows: (1) discussion of the structural aspects of protein interactions, including docking methods; (2) discussion of current and emerging methods of determining protein binding sites using both sequence-based and structure-based approaches; (3) modeling of protein-protein interactions on the basis of a diverse set of experimental techniques (e.g., mass spectroscopy, cryo-electron microscopy, cross-linking, NMR, etc); and (4) solving computational problems associated with the analysis of protein interaction networks from large-scale screening experiments (primarily two-hybrid essays and mass spectrometry). Experts from various areas of protein interactions were selected to serve on our Advisory Committee and also to present at the conference. Further presentations will be invited as well as selected by the Advisory Committee from the submitted abstracts. A poster session will be held on one of the conference days. The conference will be relatively small - approximately 100 participants. The organizers will pay special attention to attracting young investigators as speakers and poster presenters. We will encourage participation of students and postdoctoral fellows. An important aspect of the conference organization will be our effort to diversify the participation by attracting women and minority scientists. This will primarily achieved by contacting faculty members working in the areas of Biophysics and Biochemistry in minority-serving institutions.