Modeling of Protein Interactions 2007

蛋白质相互作用建模 2007

• 批准号: 7407311
• 负责人: SANDOR VAJDA
• 金额: $ 0.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-10 至 2008-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407311
• 关键词: Advisory Committees; Area; Attention; Behavior; Biochemistry; Biological; Biology; Biophysics; Cells; Collection; Complex; Cryoelectron Microscopy; Docking; Faculty; Female; Goals; Kansas; Mass Spectrum Analysis; Methodology; Methods; Minority; Minority-Serving Institution; Modeling; Numbers; Participant; Postdoctoral Fellow; Protein Structure Initiative; Proteins; Qualifying; Research Personnel; Role; Scientist; Sequence Analysis; Structure; Students; Techniques; Work; Working Women; base; concept; crosslink; day; improved; knowledge base; member; multidisciplinary; posters; protein protein interaction; protein structure; reconstruction; research study; symposium; tool

DESCRIPTION (provided by applicant): Support is requested for the multidisciplinary conference Modeling of Protein Interactions 2007 (MPI2007) to be held September 30 - October 2, 2007 in Lawrence, Kansas. The meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches. The primary goal of MPI2007 will be to critically explore the availability of tools for improving the reliability of protein interaction information, focusing on broadly defined template-based modeling of protein-protein interactions. Since the analysis is based on the structures of proteins and incorporating additional information attempts to contribute to the understanding of their cellular roles, a large scale reconstruction of protein interactions will build on the results of the Protein Structure Initiative. Some of the fundamental questions we will discuss are as follows. Will protein docking evolve in a way similar to structure prediction? In other words, will knowledge-based methods provide the most useful information, and will be there enough protein-protein templates? Does a large-scale concerted effort to determine protein-protein templates, similar to PSI, make sense, at least in principle? Is the field mature enough to meet such a challenge? How can prediction tools be combined with a diverse set of experimental techniques (e.g., mass spectroscopy, cryoelectron microscopy, cross-linking, NMR, etc) to improve reliability? Experts from various areas of protein interactions were selected to serve on the Advisory Committee and to present at the conference. Further presentations will be selected by the Advisory Committee to cover all major methodologies of protein complex determination and modeling. A growing number of highly qualified women are working in the areas covered by the conference and the female speakers will be represented in each section. A poster session will be held on one of the conference days. The conference will be relatively small - approximately 100 participants. The organizers will pay special attention to attracting young investigators as speakers and poster presenters. Participation of students and postdoctoral fellows will be encouraged. Efforts will be made to diversify the participation by attracting minority scientists and graduate students by contacting faculty members working in the areas of Biophysics and Biochemistry in minority-serving institutions. The concept of the cell as a collection of multisubunit protein machines that determine its behavior in normal and diseased states is emerging as a cornerstone of modern biology. The planned Modeling of Protein Interactions 2007 (MPI2007) meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches.

描述（由申请人提供）：支持的多学科会议建模蛋白质相互作用2007（MPI 2007）将于2007年9月30日至10月2日在劳伦斯，堪萨斯。会议将涉及生物，物理和计算科学家的组合，并将重点放在蛋白质复合物的测定，包括实验研究，基于知识的方法，序列分析和结构方法的挑战和可用的方法。MPI 2007的主要目标是批判性地探索提高蛋白质相互作用信息可靠性的工具的可用性，重点是广泛定义的基于模板的蛋白质-蛋白质相互作用建模。由于分析是基于蛋白质的结构，并结合额外的信息试图有助于理解其细胞作用，蛋白质相互作用的大规模重建将建立在蛋白质结构倡议的结果基础上。 我们将讨论的一些基本问题如下。蛋白质对接会以类似于结构预测的方式进化吗？换句话说，基于知识的方法是否能提供最有用的信息，是否有足够的蛋白质-蛋白质模板？大规模的协同努力来确定蛋白质-蛋白质模板，类似于PSI，至少在原则上是有意义的吗？这个领域是否足够成熟，能够迎接这样的挑战？如何将预测工具与各种实验技术（例如，质谱，低温电子显微镜，交联，核磁共振等），以提高可靠性？ 来自蛋白质相互作用各个领域的专家被选为咨询委员会成员并出席会议。咨询委员会将选择更多的介绍，以涵盖蛋白质复合物测定和建模的所有主要方法。越来越多的高素质妇女在会议所涉领域工作，每个部分都将有女发言人。将在其中一个会议日举行海报会议。会议规模相对较小，约100人。组织者将特别注意吸引年轻的调查人员作为演讲者和海报展示者。将鼓励学生和博士后研究员参加。将努力使参与多样化，通过与为少数群体服务的机构中从事生物物理学和生物化学领域工作的教员联系，吸引少数群体科学家和研究生。细胞作为多亚基蛋白质机器的集合，决定其在正常和疾病状态下的行为，这一概念正在成为现代生物学的基石。计划中的蛋白质相互作用建模2007（MPI 2007）会议将涉及生物，物理和计算科学家的组合，并将集中在蛋白质复合物的测定，包括实验研究，基于知识的方法，序列分析和结构方法的挑战和可用的方法。