Modeling of Protein Interactions 2007

蛋白质相互作用建模 2007

• 批准号: 7407311
• 负责人: SANDOR VAJDA
• 金额: $ 0.5万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-09-10 至 2008-09-09
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7407311
• 关键词: Advisory Committees; Area; Attention; Behavior; Biochemistry; Biological; Biology; Biophysics; Cells; Collection; Complex; Cryoelectron Microscopy; Docking; Faculty; Female; Goals; Kansas; Mass Spectrum Analysis; Methodology; Methods; Minority; Minority-Serving Institution; Modeling; Numbers; Participant; Postdoctoral Fellow; Protein Structure Initiative; Proteins; Qualifying; Research Personnel; Role; Scientist; Sequence Analysis; Structure; Students; Techniques; Work; Working Women; base; concept; crosslink; day; improved; knowledge base; member; multidisciplinary; posters; protein protein interaction; protein structure; reconstruction; research study; symposium; tool

DESCRIPTION (provided by applicant): Support is requested for the multidisciplinary conference Modeling of Protein Interactions 2007 (MPI2007) to be held September 30 - October 2, 2007 in Lawrence, Kansas. The meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches. The primary goal of MPI2007 will be to critically explore the availability of tools for improving the reliability of protein interaction information, focusing on broadly defined template-based modeling of protein-protein interactions. Since the analysis is based on the structures of proteins and incorporating additional information attempts to contribute to the understanding of their cellular roles, a large scale reconstruction of protein interactions will build on the results of the Protein Structure Initiative. Some of the fundamental questions we will discuss are as follows. Will protein docking evolve in a way similar to structure prediction? In other words, will knowledge-based methods provide the most useful information, and will be there enough protein-protein templates? Does a large-scale concerted effort to determine protein-protein templates, similar to PSI, make sense, at least in principle? Is the field mature enough to meet such a challenge? How can prediction tools be combined with a diverse set of experimental techniques (e.g., mass spectroscopy, cryoelectron microscopy, cross-linking, NMR, etc) to improve reliability? Experts from various areas of protein interactions were selected to serve on the Advisory Committee and to present at the conference. Further presentations will be selected by the Advisory Committee to cover all major methodologies of protein complex determination and modeling. A growing number of highly qualified women are working in the areas covered by the conference and the female speakers will be represented in each section. A poster session will be held on one of the conference days. The conference will be relatively small - approximately 100 participants. The organizers will pay special attention to attracting young investigators as speakers and poster presenters. Participation of students and postdoctoral fellows will be encouraged. Efforts will be made to diversify the participation by attracting minority scientists and graduate students by contacting faculty members working in the areas of Biophysics and Biochemistry in minority-serving institutions. The concept of the cell as a collection of multisubunit protein machines that determine its behavior in normal and diseased states is emerging as a cornerstone of modern biology. The planned Modeling of Protein Interactions 2007 (MPI2007) meeting will involve a combination of biological, physical, and computational scientists, and will focus on challenges and available methodologies in the determination of protein complexes, including experimental studies, knowledge-based methods, sequence analysis, and structural approaches.

描述(由申请人提供)：2007年9月30日至10月2日在堪萨斯州劳伦斯举行的蛋白质相互作用建模2007(MPI2007)多学科会议请求支持。会议将涉及生物、物理和计算科学家，并将重点讨论蛋白质复合体测定方面的挑战和可用的方法，包括实验研究、基于知识的方法、序列分析和结构方法。MPI2007的主要目标将是批判性地探索提高蛋白质相互作用信息可靠性的工具的可用性，重点是基于广泛定义的基于模板的蛋白质-蛋白质相互作用建模。由于分析是以蛋白质的结构为基础的，并纳入了有助于理解其细胞作用的额外信息，因此将在蛋白质结构倡议的结果的基础上对蛋白质相互作用进行大规模重建。我们将讨论的一些基本问题如下。蛋白质对接是否会以类似于结构预测的方式进化？换句话说，基于知识的方法会提供最有用的信息吗，是否会有足够的蛋白质-蛋白质模板？至少在原则上，类似于PSI的确定蛋白质-蛋白质模板的大规模协同努力有意义吗？这个领域是否足够成熟，可以迎接这样的挑战？如何将预测工具与各种实验技术(例如，质谱学、低温电子显微镜、交联法、核磁共振等)相结合，以提高可靠性？ 来自蛋白质相互作用各个领域的专家被选为咨询委员会成员并出席会议。咨询委员会将选择进一步的专题介绍，以涵盖蛋白质复合体测定和建模的所有主要方法。越来越多的高素质妇女在会议所涉领域工作，每一部分都将有女性发言者。其中一个会议日将举行招贴会。会议规模相对较小，约有100人参加。主办方将特别注意吸引年轻的调查人员作为演讲者和海报主持人。将鼓励学生和博士后研究员参与。将努力通过联系少数群体服务机构中生物物理和生物化学领域的教员来吸引少数群体科学家和研究生，从而使参与多样化。细胞是多亚单位蛋白质机器的集合，它们决定了细胞在正常和疾病状态下的行为，这一概念正在成为现代生物学的基石。计划中的蛋白质相互作用建模2007(MPI2007)会议将涉及生物、物理和计算科学家的组合，并将重点讨论确定蛋白质复合体的挑战和可用的方法，包括实验研究、基于知识的方法、序列分析和结构方法。