Emotion, communication, & EEG: Development & risk

描述（由申请人提供）：本项目将使用早期情感功能和沟通的发展模式来预测生命第二和第三年的社会，行为和认知功能。对比100名正常发育的婴儿兄弟姐妹和100名自闭症谱系障碍（ASD）儿童的婴儿兄弟姐妹-他们有一系列情绪，沟通和认知中断的风险-将从发展精神病理学的角度阐明这些发展过程。在生命的第一年，将确定气质（Lab-TAB）和交际（面对面/静止）对积极和消极情绪的评估、接近动机的大脑指标（脑电图偏侧性）和交际意向性（婴儿联合注意）的发展之间的联系。这些结构将用于预测一系列与发展相关的过程，包括二元关系质量、父母评定的行为困难和优势、语言和认知功能的标准化测量，以及生命第二和第三年的ASD相关症状。关系质量是一个核心结构，包括依恋的安全，父母的温暖和控制，以及孩子在一系列社会情境中的合作和温暖。除ASD症状外，关系质量有望介导所有结果的途径。具有高水平ASD症状的儿童在早期的情感沟通和后期的社会、沟通和认知功能方面都有缺陷。ASD的症状学被认为与早期情绪功能有直接关系。本研究利用幼儿早期情绪功能的多方法评估来预测有意沟通和健康互动的后期指标，以及胜任的语言和认知功能。测试的模型将在预测和预防与健康相关的结果，包括行为问题、不良关系质量和ASD症状学在一个有风险的和典型的发展样本中提供具体的启示。对正常发育的婴儿和自闭症儿童的兄弟姐妹进行预测关联的研究，将揭示健康发育的途径、这些途径的精神病理偏差，以及对有发育困难风险的婴儿的潜在干预策略。

DESCRIPTION (provided by applicant): This project will use developmental patterns of early emotional functioning and communication to predict social, behavioral, and cognitive functioning in the second and third year of life. Contrasts between 100 typically developing infant siblings and 100 infant siblings of children with Autism Spectrum Disorder (ASD) - who are at risk for a range of disruptions of emotion, communication, and cognition - will illuminate these developmental processes from a developmental psychopathology perspective. In the first year of life, associations between temperamental (Lab-TAB) and communicative (face-to-face/still-face) assessments of positive and negative emotion, cerebral indices of approach motivation (EEG laterality), and the development of communicative intentionality (infant joint attention) will be determined. These constructs will be used to predict a set of developmental^ linked processes including dyadic relationship quality, parent rated behavioral difficulties and strengths, standardized measures of linguistic and cognitive functioning, and ASD- related symptomatology in the second and third year of life. Relationship quality is a central construct, encompassing security of attachment, parental warmth and control, and child cooperation and warmeth in a range of social situations. Relationship quality is expected to mediate pathways to all outcomes with the exception of ASD symptomatology. Children with high levels of ASD symptomatology are expected to show deficits in both early measures emotional communication and later measures of social, communicative, and cognitive functioning. ASD symptomatology is expected to be directly related to early emotional functioning. This proposal utilizes multi-method assessment of emotional functioning early in infancy to confront the task of predicting intentional communication and later indices of healthy interaction, and competent linguistic and cognitive functioning. The models tested will shed specific light on the prediction and prevention of health- related outcomes including behavior problems, poor relationship quality, and ASD symptomatology in an at- risk and typically developing sample. Examination of predictive associations in typically developing infants and infant siblings of children with ASD will shed light on pathways to healthy development, psychopathologic deviations from those pathways, and potential intervention strategies for infants at risk for developmental difficulties.