Fogarty International Research Collaboration Award

描述(由申请人提供)：这份FIRCA申请描述了目前得到资助的NIH项目“墨西哥裔美国老年人的残疾过程”(2R01 AG017638，K.Ottenbacher，Pi)与哥伦比亚波哥大Pontifica University Jveriana的Envejecimiento(老龄研究所)(Carlos Cano，M.D.，主任)之间的拟议合作研究将使用两个现有数据库-拉美裔老年人流行病学研究(西班牙裔EPESE)和拉丁美洲和加勒比地区的健康、福祉和老龄化(Salud，Biestar Envejecimiento Sabe项目)。拟议的FIRCA研究的具体目的是：1.比较拉美裔老年人中两个大样本--西班牙裔EPESE和SABE研究--的虚弱发生率。2.确定是否可以使用心理健康功能水平(认知和抑郁症状)在西班牙裔EPESE和SABE数据库中识别有发展为脆弱风险的拉丁裔老年人。3.检查拉美裔老年人的心理健康功能(认知和抑郁症状)水平(西班牙裔EPESE和SABE数据库)是否调节了虚弱与健康结果(如残疾、跌倒和住院)之间的联系。这些具体目标是父母资助的研究目标的直接延伸，并从两个重要方面扩展了NIH资助的研究。首先，AIMS扩大了对残疾和脆弱的研究，包括一个代表美国以外的拉丁美洲人口的数据库(SABE)。其次，拟议的研究将在来自不同国家和文化的拉丁美洲老年人样本中提供关于认知功能与脆弱/残疾之间关系的新信息。这个总部设在美国的研究团队在涉及拉丁美洲老年人的合作研究方面有着既定的记录。PI是该大学泛美卫生组织/世卫组织老龄化与健康合作中心的主任，以前曾与哥伦比亚大学的研究人员合作过。

DESCRIPTION (provided by applicant): This FIRCA application describes a proposed collaboration between a currently funded NIH project titled, "Disablement Process in Mexican American Older Adults" (2R01 AG017638, K. Ottenbacher, PI), and the Institute de Envejecimiento (Institute on Aging) at the Pontifica Universidad Javeriana in Bogota, Columbia (Carlos Cano, M.D., Director) The collaborative research will examine the disablement process in Latino older adults using two existing databases - the Hispanic Established Populations Epidemiologic Study of the Elderly (Hispanic EPESE) and the Health, Well-Being and Aging in Latin America and the Caribbean (Salud, Bienestar y Envejecimiento) SABE project. The specific aims for the proposed FIRCA research are to: 1. Compare the incidence of frailty in two large population-based samples of Latino older adults: the Hispanic EPESE and the SABE study. 2. Determine whether level of mental health function (cognition and depressive symptoms) can be used to identify Latino older adults at risk of developing frailty in the Hispanic EPESE and SABE databases. 3. Examine whether associations between frailty and health outcomes (such as disability, falls, and hospitalization) are moderated by level of mental health function (cognition and depressive symptoms) in Latino older adults (Hispanic EPESE and SABE databases). These specific aims are a direct extension of the research aims of the parent grant and extend the NIH funded research in two important ways. First, the aims expand the study of disability and frailty to include a database representing Latin American populations outside of the U.S. (SABE). Second, the proposed research will provide new information regarding the relationship between cognitive function and frailty/disability in samples of Latin American older adults from different countries and cultures. The U.S. based research team has an established record of collaborative research involving Latin American older adults. The PI is director of the university's PAHO/WHO Collaborating Center on Aging and Health and has previous experience working with investigators from Columbia.