Epidemiology and Burden of Neurocysticercosis in Bukina Faso

描述（由申请人提供）：该项目的长期目标是通过干预可预防的原因-猪带绦虫囊虫病，减少西非布基纳法索所有年龄段人群的神经系统疾病（主要是癫痫）负担。脑囊虫病（NCC）是由T.绦虫对大脑的作用是一种可预防的，最终可根除的癫痫和其他重大神经系统并发症的原因，包括痴呆症，发生在整个年龄段。该发展阶段的主要目标是估计人类和猪中囊虫病的患病率以及癫痫的患病率和归因于NCC的比例，并估计布基纳法索囊虫病的短期和长期神经、经济和农业负担。还将探讨消除囊虫病的机会。这些目标将通过俄克拉荷马州大学健康科学中心、阿波美-卡拉维大学、帕拉库大学、公共卫生区域研究所、热带神经病学和流行病学研究所以及皇家兽医和农业大学之间的研究和培训合作来实现。探索阶段将确定相关的现有数据、对额外数据和专门知识的需求以及为满足这些需求而建设能力的机制。将进行可行性研究，以制定可接受的办法，估计今后干预措施的有效性。6个月内，将确定博士研究生，并开始进行人和猪囊虫病诊断培训。9个月后，将确定靠近2个主要城市地区的3个地区，对囊虫病和NCC的患病率进行试点研究。在未来9个月内，将对4个医疗和兽医从业人员小组进行试点研究程序的培训。这些小组将收集人和猪的血液样本，筛查村民是否有癫痫和癫痫，以及是否存在表明囊虫病的皮肤结节。在过去5年内有一次或多次癫痫发作的人将进行CT扫描，以确定可能的NCC病例。使用CT作为“金标准”，用于识别NCC的替代方法（例如，血清学或结节）进行评价。我们将评估使用日记来衡量NCC和猪囊虫病造成的经济损失的可行性。

DESCRIPTION (provided by applicant): The long-term goal of this project is to reduce the burden of neurological diseases (primarily epilepsy) in persons of all ages in Burkina Faso, West Africa through intervention on a preventable cause - Taenia solium cysticercosis. Neurocysticercosis (NCC), caused by the migration of T. solium cestodes to the brain, is a preventable, eventually eradicable, cause of epilepsy and other significant neurological complications, including dementia, that occur across the age span. The primary objectives of this developmental phase are to estimate the prevalence of cysticercosis in humans and pigs and the prevalence of epilepsy and the proportion attributable to NCC, and to estimate the short and long-term neurological, economical and agricultural burden of cysticercosis in Burkina. Opportunities for the elimination of cysticercosis will also be explored. These goals will be achieved through a research and training collaboration between the University of Oklahoma Health Sciences Center, Universite d'Abomey-Calavi, Universite de Parakou, Institut Regional de Sante Publique, Institut d'Epidemiologie Neurologique et de Neurologie Tropicale and Royal Veterinary & Agricultural University. The exploratory phase will identify relevant existing data, needs for additional data and expertise, and mechanisms to build capacities to address these needs. Feasibility studies will be conducted to develop acceptable approaches to estimating the effectiveness of future interventions. Within 6 months, doctoral degree candidates will be identified, and training in the diagnosis of human and pig cysticercosis will begin. After 9 months, 3 regions proximal to 2 major urban areas will be identified for a pilot study of the prevalence of cysticercosis and NCC. Over the next 9 months, 4 teams of medical and veterinary practitioners will be trained in the procedures for the pilot study. The teams will collect human and pig blood samples, screen villagers for seizures and epilepsy and the presence of skin nodules indicative of cysticercosis. Persons who have had one or more seizures within the previous 5 years will have a CT scan to identify possible cases of NCC. Using CT as the "gold standard", the validity of alternative methods for identifying NCC (e.g., serology or nodules) will be evaluated. We will assess the feasibility of using a diary for measuring the monetary losses attributable to NCC and pig cysticercosis.