Data Management, Statistics, and informatics Core

描述（由申请人提供）：应RFA-HD-04-002题为“早产儿研究基因组和蛋白质组学网络”的要求，我们建议在耶鲁大学建立一个数据管理、统计和信息学核心，作为该网络的一部分。我们将负责中央数据库、数据分析和管理；信息技术;以及协调该网络的行政活动。我们已经组建了一个在所有这些领域具有丰富经验的调查小组，我们在相关活动中进行了密切和成功的合作。具体来说，作为网络的一部分，我们将(1)建立和维护一个中央数据库，进行数据分析、信息技术；(2)与三个临床核心的研究者合作，确定研究假设，并在研究设计中发挥领导作用；(3)与研究人员互动，分析基因组和蛋白质组学数据；(4)建立并维护一个公共的、基于网络的基因组和蛋白质组学数据库，供研究界和我们的网络进行数据挖掘和数据存储；(5)参与网络的指导委员会，协调和管理网络的核心活动，并定期与NICHD项目工作人员和网络调查员进行沟通；(6)与网络研究者一起参与稿件编写和发表，通过网络网站及时传播科学成果；(7)开展与RFA目标一致的研究活动，即加快对早产病理生理学的深入了解，发现新的靶分子和诊断生物标志物，并最终帮助制定更有效的干预措施来预防早产。

DESCRIPTION (provided by applicant): As requested by RFA-HD-04-002 entitled "Genomic and Proteomic Network for Premature Birth Research," we propose to establish a Data Management, Statistics, and Informatics Core at Yale University as a part of the Network. We will be responsible for the central database, data analysis, and management; information technology; and coordination of the administrative activities of the Network. We have assembled a team of investigators with extensive experience in all of these areas, and we have collaborated closely and successfully in related activities. Specifically, as a part of the Network, we will (1) establish and maintain a central database, data analysis, information technology;(2) collaborate with investigators in the three clinical cores to define the study hypotheses and play a leadership role in the study design;(3) interact with investigators in the analytic core for analyzing genomic and proteomic data;(4) establish and maintain a public, web-based, genomic and proteomic database for data mining and data deposition by the research community as well as within our network;(5) participate in the steering committee of the network, coordinate and administrate activities central to the network and communicate regularly with the NICHD program staff and the network investigators;(6) participate in manuscript preparation and publication with the network investigators, and disseminate scientific results timely through the network website;(7) initiate our own research activities consistent with the goal of the RFA, namely to hasten a deeper understanding of the patho-physiology of premature birth, discover novel target molecules and diagnostic biomarkers, and ultimately aid in formulating more effective interventions to prevent premature birth.