UCSD Mouse Research Facilities Improvement Program-Leichtag Bldg.

描述（由申请人提供）： 在加州大学圣地亚哥分校（UCSD）校园内的四个“屏障型”设施中，生物医学研究动物园包括18个房间，可容纳108个架子和17，000多箱研究小鼠。要求提供资金购买24个高密度老鼠笼系统，以扩大UCSD校园内可用住房空间的容量。在UCSD，与疾病相关的基因组和转化研究是首要任务。拟议的住房扩建将使建立和新招募的教师进行癌症生物学，血液学，内分泌学，糖生物学和毒理学的开创性研究。在这些领域的发现将促进预防和安全治疗重要的人类疾病，如癌症，阿尔茨海默氏症和糖尿病。近年来，越来越明显的是，免疫缺陷小鼠品系和靶基因缺陷小鼠需要更严格的维持水平，以排除不必要的病原体暴露。这种“屏障型”设施对于保持动物的健康以及防止由隐性感染和细胞因子/趋化因子释放引起的虚假实验结果至关重要。 加州大学圣地亚哥分校动物护理和使用计划的首要目标是最大限度地提高成功的研究，优化动物福利，并确保人类健康。我们目前正专注于“屏障型”动物园，我们正在升级参与PHS资助研究的小鼠的住房系统。这些升级后的饲养系统将有助于我们努力保持至关重要的动物健康，并且没有不需要的小鼠微生物和病原体。 我们的具体目标是：1）扩大“屏障型”小动物研究设施的能力; 2）通过尽量减少病原体的暴露来改善小鼠的健康; 3）促进实验结果的标准化。为了实现这些目标，我们希望用这笔赠款购买108个高密度单独通风小鼠住房系统中的24个，这些系统需要支持对相关微生物区系相对较小变化敏感的关键研究动物。大学将在资金到位时提供其余44个机架。

DESCRIPTION (provided by applicant): Amongst the four "barrier-type" facilities on the campus of the University of California, San Diego (UCSD), the Liechtag Biomedical Research vivarium includes18 rooms capable of supporting 108 racks and over 17,000 boxes of research mice. Funds are requested to purchase 24 high density mouse caging systems to expand the capacity of available housing space on the UCSD campus. At UCSD, diseaserelated genomic and translational research is a foremost priority. The proposed housing expansion will enable established and newly recruited faculty to conduct seminal studies in cancer biology, hematology, endocrinology, glycobiology, and toxicology. Discoveries in these areas will advance the prevention and safe treatment of important human diseases such cancer, Alzehiemer's and diabetes. In recent years it has become increasingly apparent that immunodeficient mouse strains and mice that are deficient in targeted genes require a stricter level of maintenance that precludes unwanted pathogen exposure. Such "barrier-type" facilities are critical to maintain the health of the animals and also to prevent spurious experimental results from occult infection and cytokine/chemokine release. Top Goals for the Animal Care and Use Program at UCSD are to maximize successful research, optimize animal well being, and ensure human health. We are currently focusing on "barrier-type" vivaria where we are upgrading housing systems for mice involved in PHS funded research. These upgraded housing systems will aid our efforts to maintain critically important animals healthy and free of unwanted mouse microbial agents and pathogens. Our specific aims are 1) to expand the capacity of "barrier-type" small animal research facilities, 2) to improve the health of mice by minimizing exposure to pathogens; and 3) to facilitate standardization of experimental results. To address these aims we wish to purchase with this grant 24 of the 108 high density individually ventilated mouse housing systems that are needed to support critical research animals sensitive to relatively minor changes in associated microflora. The University will provide the remaining 44 racks as funds become available.