Exploring surface energies and their impact in pharmaceutical crystals

如果能够将表面结构和能量与表面特性（如附着力、凝聚力和润湿性）的变化联系起来，就可以更有效地进行早期颗粒风险评估。该项目旨在测量许多药物晶体（卡马西平和扑热息酚）的表面能（反气相色谱法和接触角测量），并将它们与各种计算机模拟进行比较。这种分析将能够更有效地突出颗粒属性风险，并为药物颗粒开发设计和及时提供信息。这种类型的预测对配方设计特别有价值，并有助于理解粉末共混物的团聚、偏析和静电电荷。

Having the ability to link surface structure and energies to changes in surface properties such as adhesion, cohesion and wettability would allow for a more effective early particle risk assessment. This project seeks to measure surface energies (inverse gas chromatography and contact angle measurements) in a number of pharmaceutical crystals (carbamazepine and paracetamol) and compare them to various computer simulations. This analysis would enable a more effective highlight of particle property risks and devise and inform timely strategies for pharmaceutical particle development. This type of prediction is particularly valuable for formulation design and would lead to understanding of agglomeration, segregation and electrostatic charging of powder blends.