FINDING NEW AVENUES TO OVERCOME CHEMORESISTANCE FOR IMPROVED CANCER THERAPY

对于许多癌症患者来说，获得治愈或更长时间缓解的最大希望在于通过靶向细胞存活途径或以某种方式重新启动化疗反应来有效杀死肿瘤细胞的新药。我们的目标是开发能够中和促生存蛋白的新型小分子。此外，我们的目标是确定新的肿瘤抑制基因，其中一些可能代表癌症治疗的有吸引力的目标。

For many patients with cancer, the best hope for obtaining cures or much longer remission lies in new drugs that efficiently kill the tumour cells by targeting cell survival pathways or by somehow reinstalling chemotherapeutic response. We aim to develop novel small molecules able to neutralise pro-survival proteins. Furthermore, we aim to identify new tumour suppressor genes, some of which are likely to represent attractive targets for cancer therapy.