CORE GRANT IN VISION RESEARCH

描述(由申请人提供)：范德比尔特视力研究中心(VVRC)横跨文理学院、皮博迪教育学院、工程学院和医学院，要求不间断地支持四个模块和一个新模块。(1)动物护理单元提供非人类灵长类动物和其他大型动物的专门饲养、繁殖、外科支持和兽医护理，以及转基因小鼠的基因鉴定和表型鉴定。这些服务不是由范德比尔特动物保育部提供的。(2)计算机模块提供硬件安装和维护、可视化显示和实时数据采集和分析的软件开发、网页维护以及为期刊、幻灯片和海报制作插图。(3)图像处理模块辅助光学成像、功能磁共振成像等成像数据的采集和分析。本模块还将提供对共焦显微镜的访问和支持。(4)车间模块负责维修、设计和制造专业的光学、机械和电子仪器。还要求为新的基因和蛋白质分析模块提供支助，该模块将提供获得基因微阵列和蛋白质质谱学服务的经济途径。需要行政支助，以确保志愿人员伤亡控制中心研究和培训任务继续顺利和稳定地运作。模块由NEI资助的调查人员指导，拥有才华横溢且经验丰富的工作人员，并提供否则无法获得或将昂贵得令人望而却步或速度缓慢的服务。在上一次赠款期间，至少有五名调查员适度或广泛地使用了每个模块。VVRC研究人员制作了数百份出版物，为基础和临床视觉科学做出了根本性贡献。Core补助金增加了范德比尔特校园内基础和临床视力研究人员之间以及与其他机构之间的合作。核心资助提高了我们向范德比尔特招聘世界级视觉研究人员的能力，从而使范德比尔特的NEI赞助的研究增加了一倍。VVRC研究人员的高水平表现依赖于新的核心拨款支持，这与范德比尔特大学在生物医学研究和培训方面的校园倡议相结合。

DESCRIPTION (provided by applicant): The Vanderbilt Vision Research Center (VVRC) spanning the College of Arts & Science, Peabody College of Education, School of Engineering and School of Medicine requests uninterrupted support for four modules plus support for one new module. (1) The Animal Care Module provides specialized breeding, enrichment, surgical support and veterinary care of nonhuman primates and other large animals as well as genotyping and phenotyping of transgenic mice. These services not provided by the Vanderbilt Division of Animal Care. (2) The Computer Module provides hardware installation and maintenance, software development for visual displays and real-time data acquisition and analysis, webpage maintenance and production of illustrations for journals, slides and posters. (3) The Image Processing Module aids acquisition and analysis of optical imaging, fMRI and other imaging data. This module will also provide access to and support of confocal microscopy. (4) The Shop Module repairs, designs and fabricates specialized optical, mechanical and electronic instruments. Support is also requested for a new Gene & Protein Analysis Module that will provide economical access to gene microarray and protein mass spectrometry services. Administrative support is requested to ensure continued smooth and stable operation of the VVRC research and training missions. Modules are directed by investigators with NEI funding, have talented and experienced staff and provide services that are otherwise not available or would be prohibitively expensive or slow. During the last grant period, each module was used moderately or extensively by no less than five investigators. VVRC investigators produced several hundred publications that made fundamental contributions to basic and clinical visual science. The Core grant has increased collaborations between basic and clinical vision researchers across the Vanderbilt campus and with other institutions. The Core grant has improved our ability to recruit world-class vision researchers to Vanderbilt resulting in a more-thandoubling of NEI-sponsored research at Vanderbilt. The high level of performance of VVRC investigators, which depends on renewed Core grant support, synergizes with campus-wide initiatives in biomedical research and training at Vanderbilt.