Core--Biochemistry and Signal Transduction

生物化学核心和信号转导核心是独立的单元。它们在本次更新申请中被合并，因为它们使用类似的方法，并且使用可以在两个核心中执行某些分析的人员。此外，在当前的资助期内，信号转导核心的部分工作涉及开发受体和其他信号分子的遗传变异的方法和鉴定。这些工作现在将由d核心承担。生物化学核心和信号转导核心的合并将使核心董事的共同努力从10%减少到8%，并允许人员共同努力，从而提高运作效率。由此产生的效率反映在预算中，该预算低于目前运行的两个核心的合并预算。虽然总化验次数进行了

The Biochemistry Core and Signal Transduction Core were separate units. They have been combined in this renewal application since they utilize similar methods and utilize personnel who can perform some of the assays in both cores. In addition, part of the efforts of the Signal Transduction Core during the current funding period involved development of methods and identification of genetic variants in receptors and other signaling molecules. These efforts will now be undertaken by Core D. The combination of the Biochemistry and Signal Transduction Cores will permit more efficient operation by decreasing the combined effort of the core directors from 10% to 8% and by allowing personnel to combine efforts. The resulting efficiencies are reflected in the budget, which is less than the combined budgets of the two cores currently in operation. Although the total number of assays performed by the cores will not decrease, laboratory personnel are now more familiar with performing high volume assays, and can thus carry them out more efficiently. Unfortunately, supplies for these assays have not gone down in price, so we have not been able to decrease the supply budget as much as the personnel budget.