Pediatric Hematology and Oncology Research

描述（由申请人提供）：本竞争性续期申请的目的是要求继续国家服务研究奖支持四个儿科血液肿瘤学研究员每年（两个第二年和两个第三年）在儿科在德克萨斯大学西南医学中心在达拉斯（UT西南）。这些奖项将用于支持年轻儿科医生的研究培训，他们已经完成了一年的临床研究金，致力于患者诊断和管理以及研究方法的接触。在UT西南部的儿科血液肿瘤学奖学金计划是在20世纪80年代中期开发的，其广泛的目标是培训致力于全职职业生涯的医生在学术竞技场，鉴于临床和实验室学者在儿科血液肿瘤学的持续国家短缺的一个至关重要的需求。这个奖学金培训计划在UT西南的持续成功是有保证的，鉴于：（1）大量、多样且易于获得的患者群体，（2）在诸如癌症治疗、分子肿瘤学、癌症存活率、镰状细胞病、出血性和血栓性疾病、肿瘤支持性护理和癌症遗传学等领域的临床和实验室研究卓越的跟踪记录，（3）与杰出的基础科学研究者的良好合作和承诺，以及（4）现有的基础设施和以患者为导向的研究的主要新机构倡议。这些特点合在一起，为获得所要求的津贴支助的研究员进行尖端研究培训提供了良好的环境。现任和前任儿科血液肿瘤学实习生在不同研究领域的研究者指导下工作。自1990年首次授予以来，已有31名受训人员获得了国家登记局的机构支助，其中大多数人成功地成为临床或实验室调查员，或继续成为研究员。在儿科血液肿瘤科及其多个合作实验室和临床研究领域在UT西南部的刺激智力参与将继续为学员成为独立的研究者提供必要的丰富的环境。

DESCRIPTION (provided by applicant): The purpose of this competitive renewal application is to request continued National Service Research Award support for four pediatric hematology-oncology fellows annually (two second-year and two third-year) in the Department of Pediatrics at The University of Texas Southwestern Medical Center at Dallas (UT Southwestern). These awards will be used to support research training of young pediatricians who have completed a clinical fellowship year devoted to patient diagnosis and management and exposure to research methods. The pediatric hematology-oncology fellowship program at UT Southwestern was developed in the mid-1980's with the broad aim of training physicians committed to full-time careers in the academic arena, a vital need in view of the continued national shortage of clinical and laboratory scholars in pediatric hematology-oncology. The continued success of this fellowship training program at UT Southwestern is assured, given: (1) a large, diverse, and readily accessible patient population, (2) a track record of clinical and laboratory investigative excellence in areas such as cancer therapeutics, molecular oncology, cancer survivorship, sickle cell disease, hemorrhagic and thrombotic disorders, oncologic supportive care, and cancer genetics, (3) well functioning collaborations with and commitment from outstanding basic science investigators, and (4) existing infrastructure and major new institutional initiatives on patient-oriented research. These features combined provide an excellent environment for cutting-edge research training of fellows supported by the requested stipends. Current and former pediatric hematology-oncology trainees have worked under the preceptorship of investigators in diverse research areas. Since the initial award in 1990, thirty-one trainees have received institutional NRSA support and most have been successful as clinical or laboratory investigators or continue as fellows. The stimulating intellectual involvement in the Division of Pediatric Hematology-Oncology and its multiple collaborating laboratories and clinical research domains at UT Southwestern will continue to provide the rich milieu necessary for trainees to become independent investigators.