Role of Thermoregulation in MDMA Abuse

描述（由申请人提供）： 本申请提出通过静脉内自我给药和体内微透析方法，在非人灵长类药物滥用模型中评估环境温度和甲状腺激素水平对3，4-亚甲二氧基甲基苯丙胺（MDMA）强化作用的影响。我们将在22摄氏度和28摄氏度的环境温度下，使用同时选择程序比较自我管理的MDMA的强化和高热效应。此外，将在前两个环境温度下评估腹侧纹状体内由MDMA诱导的中枢多巴胺释放。最后，还将评估长期甲状腺素治疗对MDMA诱导的中枢多巴胺释放、体温过高和自我给药的影响。该提案旨在阐明MDMA强化效应的潜在机制，并更深入地了解甲状腺激素和环境温度对MDMA滥用的影响。了解MDMA诱导强化的行为和神经化学机制将有助于提高公众意识，并为MDMA滥用相关毒性提供更好的药物治疗。

DESCRIPTION (provided by applicant): This application proposes to assess the effects of ambient temperature and thyroid hormone levels on the reinforcing effects of 3,4-methylenedioxymethamphetamine (MDMA) in a non-human primate model of drug abuse through methods of intravenous self-administration and in vivo microdialysis. We will compare the reinforcing and hyperthermic effects of self-administered MDMA using a concurrent choice procedure at ambient temperatures of 22 degrees C and 28 degrees C. Also, central dopamine release induced by MDMA within the ventral striatum will be assesed at the previous two ambient temperatures. Finally, the effects of chronic thyroxine treatment on MDMA-induced central dopamine release, hyperthermia and selfadministration will also be evaluated. This proposal aims to elucidate potential mechanisms involved in the reinforcing effects of MDMA and provide a more thorough understanding of the effects of thyroid hormone and ambient temperature on MDMA abuse. Understanding the behavioral and neurochemical mechanisms involved in MDMA-induced reinforcement will allow for increased public awareness and better pharmacotherapies for the toxicities associated with MDMA abuse.