Multidisciplinary Training in Pulmonary Research

描述(由申请人提供)： 这一机构国家研究服务奖旨在培养具有研究导向的职业技能的研究人员，旨在解决肺部疾病的基本和临床问题。该计划的结构基于这样的前提，即培训需要1)多学科方法，2)学生和导师之间的密切关系，以及3)在临床和基础科学方面都有广度和深度的培训环境。该项目的培训涉及多个学科，包括细胞和分子生物学、免疫学、微生物学、毒理学、生物化学、肺部和重症监护医学、新生儿学和成像科学。主要研究主题包括肺免疫学和炎症、肺损伤的分子基础、气体和颗粒性空气污染物对健康的影响、血管功能和生物学，以及肺部炎症和纤维化动物模型的成像技术。该项目每年将资助4名博士后和4名博士后实习生。对肺部研究表现出兴趣的博士前学生将在通过初步考试后，通过生物医学研究生教育(GEBS)群组接受培训。博士前实习生将获得为期三年的支持。在成人肺部和重症护理医学、新生儿和传染病方面的培训项目的博士后MD候选人将被考虑在以肺部研究为导向的职业生涯中取得潜在成功。支持将为期两年，并将在他们完成大部分临床培训后开始。参与肺部相关研究的博士后实习生也是培训的候选人，并由本培训计划的教职员工确定和招募。共有四名博士后实习生将得到支持。与研究导师的直接研究经验形成了主要的培训机制，辅以教学课程、研讨会、会议、期刊俱乐部以及研究伦理和人类和动物实验方面的指导。受训者将在他们的导师和具有适当研究领域专业知识的跨学科教员组成的委员会的密切监督下制定研究方案。这一培训计划将有助于满足对肺部生物学和疾病科学研究人员日益增长的需求。这些年轻研究人员的研究将提高我们对呼吸系统如何应对伤害和环境挑战的理解，并将通过开发新的和改进的肺部疾病预防和治疗途径来改善公众健康。(摘要结束)

DESCRIPTION (provided by applicant): This Institutional National Research Service Award is designed to develop skilled investigators with research-oriented careers directed at solving basic and clinical problems in lung disease. The structure of the program is based on the premise that training requires 1) a multidisciplinary approach, 2) a close relationship between the student and mentor, and 3) a training environment with breadth and depth in both clinical and basic sciences. Training in this program spans a variety of disciplines, including cell and molecular biology, immunology, microbiology, toxicology, biochemistry, pulmonary and critical care medicine, neonatology, and imaging sciences. Major research themes include lung immunology and inflammation, the molecular basis of lung injury, health effects of gaseous and particulate air pollutants, vascular function and biology, and imaging techniques in animal models of pulmonary inflammation and fibrosis. Four pre-doctoral and four post-doctoral trainees will be supported each year of the program. Pre-doctoral students who have demonstrated an interest in lung research will be accepted for training through the Graduate Education in Biomedical Sciences (GEBS) clusters, after they have passed their preliminary examinations. Pre-doctoral trainees will be supported for three years. Post-doctoral MD candidates from training programs in adult Pulmonary and Critical Care Medicine, Neonatology, and Infectious Disease will be considered based on potential success in a pulmonary research-oriented career. Support will be for two years, and will commence after the bulk of their clinical training is completed. Post-doctoral PhD trainees involved in lung-related research are also candidates for training, and are identified and recruited by faculty members of this training program. A total of four post-doctoral trainees will be supported. A direct research experience with research mentors forms the primary mechanism for training, supplemented by didactic courses, seminars, conferences, journal clubs, and instruction in research ethics, and human and animal experimentation. Trainees will develop research protocols under the close supervision of their mentors and of a committee from the interdisciplinary faculty with expertise in the appropriate field of research. This training program will help to meet the increasing need for scientific investigators in lung biology and disease. Research by these young investigators wjll improve our understanding of how the respiratory system responds to injury and environmental challenges, and will improve public health by developing new and improved avenues for the prevention and treatment of lung disease. (End of Abstract)