Multidisciplinary Training in Pulmonary Research

描述（由申请人提供）：摘要这个机构的国家研究服务奖旨在培养熟练的调查人员与研究为导向的职业生涯，旨在解决肺部疾病的基本和临床问题。该计划的结构是基于这样的前提，即培训需要1）多学科方法，2）学生和导师之间的密切关系，以及3）在临床和基础科学的广度和深度的培训环境。该计划的培训涵盖了各种学科，包括细胞和分子生物学，免疫学，微生物学，毒理学，生物化学，肺部和重症监护医学，传染病，泌尿外科学和成像科学。主要研究主题包括肺免疫学，炎症和感染;肺纤维化和重塑;烟草烟雾和慢性阻塞性肺病;以及空气污染对健康的影响。该计划每年将支持4名博士前和4名博士后学员。谁已经表现出对肺部研究的兴趣的博士前学生将被接受通过生物医学科学（GEBS）计划的研究生教育的培训，他们已经通过了初步考试后。博士前培训生将获得长达3年的支持。在这份重新提交的提案中，博士后医学博士培训的结构和课程已经改变，创建了一个新的研究轨道，要求在最后2年进行4年的亚专业培训，并提供研究培训和支持，以及在培训结束时提交出版物和研究补助金的具体期望。来自成人肺和重症监护医学，过敏/免疫学/流变学，新生儿学和传染病培训课程的候选人将根据在肺部研究型职业生涯中的潜在成功和承诺进行考虑。参与肺相关研究的博士后博士学员也是培训的候选人，并由该计划的成员确定和招募。与研究导师的直接研究经验形成了培训的主要机制，辅以教学课程，研讨会，会议，期刊俱乐部，以及研究伦理，人类和动物实验和赠款写作的指导。学员将在导师的密切监督下制定研究方案，并获得特定项目和导师委员会的学术和职业指导。该培训计划将有助于满足对肺部生物学和疾病科学研究人员日益增长的需求。这些年轻研究人员的研究将提高我们对呼吸系统如何应对伤害和环境挑战的理解，并将通过开发新的和改进的预防和治疗肺部疾病的途径来改善公共卫生。

DESCRIPTION (provided by applicant): Abstract This Institutional National Research Service Award is designed to develop skilled investigators with research- oriented careers directed at solving basic and clinical problems in lung disease. The structure of the program is based on the premise that training requires 1) a multidisciplinary approach, 2) a close relationship between the student and mentor, and 3) a training environment with breadth and depth in both clinical and basic sciences. Training in this program spans a variety of disciplines, including cell and molecular biology, immunology, microbiology, toxicology, biochemistry, pulmonary and critical care medicine, infectious diseases, neonatology, and imaging sciences. Major research themes include lung immunology, inflammation and infection; pulmonary fibrosis and remodeling; tobacco smoke and chronic obstructive pulmonary disease; and health effects of air pollution. Four predoctoral and 4 postdoctoral trainees will be supported each year of the program. Predoctoral students who have demonstrated an interest in lung research will be accepted for training through the Graduate Education in Biomedical Sciences (GEBS) programs, after they have passed their preliminary examinations. Predoctoral trainees will be supported for up to 3 years. In this resubmitted proposal, the structure and curriculum for postdoctoral MD training has been changed, with creation of a new research track, requirement for 4 years of subspecialty training with research training and support on this grant occurring in the final 2 years, and specific expectations of publications and research grant submission by the end of training. Candidates from training programs in adult Pulmonary and Critical Care Medicine, Allergy/Immunology/Rheumatology, Neonatology, and Infectious Diseases will be considered based on potential success in and commitment to a pulmonary research-oriented career. Postdoctoral PhD trainees involved in lung-related research are also candidates for training, and are identified and recruited by members of this program. A direct research experience with research mentors forms the primary mechanism for training, supplemented by didactic courses, seminars, conferences, journal clubs, and instruction in research ethics, human and animal experimentation, and grant writing. Trainees will develop research protocols under the close supervision of their mentors, with academic and career guidance from specific programs and a Mentoring Committee. This training program will help to meet the increasing need for scientific investigators in lung biology and disease. Research by these young investigators will improve our understanding of how the respiratory system responds to injury and environmental challenges, and will improve public health by developing new and improved avenues for the prevention and treatment of lung disease.