TRAINING GRANT IN NEURODEVELOPMENTAL DISABILITIES

描述（由申请人提供）：据估计，发育障碍影响了美国10%的家庭。迫切需要愿意并能够应用现代研究方法来阐明这些疾病的发病机制和病理生理学的研究人员，以便确定新的和更有效的治疗干预措施。我们在费城儿童医院（CHOP）和宾夕法尼亚大学（U of P）的跨学科机构博士后神经发育障碍培训计划的目的是培养医学博士 博士和博士后研究员，研究重点是导致智力迟钝和发育障碍的遗传和后天性疾病。19名导师将参加该计划的第一次竞争性更新; 13名主要在CHOP，6名主要在P.所有人都积极参与生物医学研究生教育，并通过相互研究项目和赠款密切相关。除了指导研究培训，我们的课程强调医学博士和博士的临床实习要求，通过P研究生课程的U正式课程工作，以及生物伦理学，生物统计学和科学写作和演示技能的培训。在我们计划的前4年，我们接受了8名实习生，其中2名是医学博士，5名博士，1名是医学博士/博士。迄今为止完成我们项目的5人中，2人获得了初级教师职位，2人在重返学术生涯之前进入了临床培训项目（1人在神经病学，1人在神经外科），1人接受了生物技术公司的职位。另外两名学员将在未来一年内完成我们的计划;每个人都已获得并接受了医学院助理教授职位（1名在神经病学和儿科学，P的U，另一名在精神病学，UCLA）。我们被批准为4博士后研究员/年在我们的前5年，并要求在未来5年相同的资金水平。

DESCRIPTION (provided by applicant): It has been estimated that developmental disabilities affect 10% of all families in the USA. Researchers are urgently needed who are willing and able to apply modern research methods to elucidating the pathogenesis and pathophysiology of these disorders, so that new and more effective therapeutic interventions can be identified. The aim of our interdisciplinary Institutional Post-doctoral Training Program in Neurodevelopmental Disabilities, based at The Children's Hospital of Philadelphia (CHOP) and The University of Pennsylvania (U of P), is to train MD and PhD post-doctoral fellows in research focused on genetic and acquired disorders that cause mental retardation and developmental disability. Nineteen Mentors will participate in this first competitive renewal of this program; 13 are based primarily at CHOP, and 6 primarily at the U of P. All are heavily involved in biomedical graduate education and are closely interlinked by mutual research projects and grants. In addition to mentored research training, our curriculum emphasizes a clinical practicum requirement for both MDs and PhDs, formal course work through the U of P Graduate Studies Program, and training in bioethics, biostatistics, and skills in scientific writing and presentation. During the first 4 years of our program, we accepted 8 Trainees, of whom 2 were MDs, 5 PhDs, and 1 and MD/PhD. Of the 5 who have thus far completed our program, 2 have obtained junior faculty positions, 2 have entered clinical training programs (1 in neurology, 1 in neurosurgery) prior to returning to an academic career, and 1 accepted a position in a biotechnology firm. Two additional Trainees will complete our program during the coming year; each has been offered and accepted a medical school assistant professorship (1 in Neurology and Pediatrics, U of P, the other in Psychiatry, UCLA). We were approved for 4 post-doctoral fellows/year during our first 5 years, and request the same level of funding for the next 5 years.