New Perspectives in Transporter Biology (FASEB Conference)

描述(由申请人提供)：本申请是对将由美国实验生物学学会联合会(FASE B)主办的题为“转运蛋白生物学的新视角”的会议的支持请求。关于这一主题的第五届FASE B会议计划于2005年7月23日至7月28日在佛蒙特州萨克斯顿河的佛蒙特州学院举行。 这次会议的重点是转运蛋白，这是一大类膜蛋白，对不同的现象至关重要，包括营养物质的吸收和分布，代谢物的选择性肾脏排泄，分子跨血脑屏障的运动，将神经递质包装成小泡，以及突触释放的神经递质的清除/终止。在过去的15年里，由于克隆和随后可用于研究的工具(抗体、表达系统等)的开发，转运蛋白过程研究的复杂性有了显著的提高。过去一年半是转运蛋白生物学的分水岭。现在已经有了关于该家族少数成员的结构信息，这是我们对人类多态研究带来的药物代谢/作用的基因组学理解的日益成熟，并且已经开发了新的技术/模型系统来研究转运蛋白生物学。 这些转运蛋白的功能改变和/或突变与多种疾病有关，包括癫痫、头部创伤、肌萎缩性侧索硬化症(ALS)、抑郁症、注意力缺陷多动障碍(ADHD)、糖尿病、直立性低血压、胱氨酸尿症、囊性纤维化、HHH综合征等。尽管一些药物针对这些转运蛋白(抗抑郁药、抗癫痫药、治疗ADHD的药物)，但考虑到这类功能相关蛋白质所代表的膜靶点的数量，这仍然是令人惊讶的少量药物。 这次会议汇集了使用结构、生物物理、分子、药物基因组学、生化、细胞生物学和生理学技术来研究这些蛋白质的个人。此外，它还将对不同器官系统和疾病过程感兴趣的个人聚集在一起。这次会议的一个压倒一切的目标是促进研究转运蛋白的不同学科之间的交叉受精和合作。这次会议的长期目标是培养将以编程方式合作研究这一重要类别的膜蛋白的个人联合体。

DESCRIPTION (provided by applicant): This application represents a request for support of a conference that will be held under the auspices of the Federation of American Societies of Experimental Biology (FASEB), entitled "New Perspectives in Transporter Biology". The fifth bi-annual FASEB conference on this topic is scheduled to occur at Vermont Academy in Saxtons River, Vermont starting on July 23rd and ending on July 28th of 2005. This conference focuses on transporters, a large class of membrane proteins that are essential for diverse phenomena, including absorption and distribution of nutrients, selective renal excretion of metabolites, movement of molecules across the blood brain barrier, packaging of neurotransmitters into vesicles, and clearance/termination of synaptically released neurotransmitter. Over the last 15 years, the sophistication of studies of transporter processes has dramatically improved because of the cloning and subsequent development of tools (antibodies, expression systems, etc) that can be used for their study. The past year and half have been a watershed in transporter biology. There is now structural information on a few members of the family, this is increasing sophistication in our understanding of the genomics of drug metabolism/action brought about by studies of human polymorphisms, and new techniques/model systems have been developed to study transporter biology. Altered function and/or mutations in these transporters have been implicated in diverse diseases, including epilepsy, head trauma, amyotrophic lateral sclerosis (ALS), depression, attention deficit hyperactivity disorder (ADHD), diabetes, orthostatic hypotension, cystinuria, cystic fibrosis, HHH syndrome, etc; there is a growing list of 'transporteropathies'. Although some drugs target these transporters (anti-depressants, antiseizure, drugs to treat ADHD), this is still a surprisingly small number of drugs considering the number of membrane targets represented by this class of functionally related proteins. This meeting brings together individuals who use structural, biophysical, molecular, pharmacogenomic, biochemical, cell biological, and physiological techniques to study these proteins. Furthermore, it brings together individuals who have interests in diverse organ systems and disease processes. An over-riding goal of this meeting is to facilitate cross-fertilization and collaboration between the various disciplines that study transporters. The long-term goal of this meeting is to cultivate consortiums of individuals who will work together programmatically to study this important class of membrane proteins.