Pulmonary Pathogen Defense Mechanisms

描述（由申请人提供）： 凯斯西储大学（CWRU）的肺宿主防御微生物病原体（HL-07889）博士后培训项目的竞争性更新申请旨在为医学博士的研究培训项目提供更新资金，医学博士博士和博士科学家 1998年7月，在CWRU对结核病、艾滋病和囊性纤维化并发症的研究项目的支持下，为这一新的培训项目提供了资金。 CWRU的肺部宿主防御研究仍然是一个机构的优势，国际公认的教师与主要肺部病原体，如M。结核病、HIV-1、肺炎链球菌和铜绿假单胞菌。研究宿主对这些细菌和病毒性肺部病原体的防御的跨学科方法涉及基础和临床部门的教师，包括免疫学，分子生物学，生物化学，遗传学和细胞生物学。 CWRU在肺宿主防御微生物病原体领域的跨学科合作得到了结核病研究单位（TBRU），艾滋病研究中心（CFAR），艾滋病临床试验单位（ACTU），囊性纤维化中心和NIH资助的临床研究中心（GCRC）的基础设施的极大促进。 此外，儿科和医学系的强大基础研究项目与临床科学家密切合作，创造了一个丰富的环境，使学员能够学习基础研究如何转化为临床研究。 研究培训计划的目标是： 1.为有前途的医学博士提供严格的训练，医学博士博士和博士博士后研究员在应用免疫学，分子生物学或生物化学的工具，肺部宿主防御病原体，如M。结核病和艾滋病毒I。 2.通过培训和协助学员获得额外博士后培训或教师发展的资金，在职业发展中发挥积极作用，这取决于他们在进入培训计划和培训计划发展时的培训水平。

DESCRIPTION (provided by applicant): This competitive renewal application for a postdoctoral training program in pulmonary host defenses to microbial pathogens (HL-07889) at Case Western Reserve University (CWRU) seeks renewal funding for a research training program for M.D.,M.D.-Ph.D. and Ph.D. scientists. Funding for this novel training program was awarded in7/1998 on the strength of there search programs at CWRU in programmatic are as of tuberculosis, HIV and complications of cystic fibrosis. Research in pulmonary host defenses at CWRU has remained an institutional strength, with internationally recognized faculty with research programs on major pulmonary pathogens such as M. tuberculosis, HIV-1, Streptococcus pneumonia and Pseudomonas aeruginosa. Interdisciplinary approaches to study of host defenses to these bacterial and viral pulmonary pathogens involve faculty across basic and clinical departments and include immunology, molecular biology, biochemistry, genetics and cell biology. The interdisciplinary collaborations at CWRU in the area of pulmonary host defenses against microbial pathogens are greatly facilitated by the infrastructures of the Tuberculosis Research Unit (TBRU), the Center for AIDS Research (CFAR), the AIDS Clinical Trails Unit (ACTU), the Cystic Fibrosis Center and the NIH-funded Clinical Research Center (GCRC). In addition, strong basic research programs in the Departments of Pediatrics and Medicine in close proximity to and collaboration with clinical scientists has created a rich environment allowing trainees to learn how basic research translates into clinical investigation. The goals of the research training program are: 1. To provide rigorous training for promising M.D., M.D.-Ph.D. and Ph.D. postdoctoral fellows in the application of the tools of immunology, molecular biology or biochemistry to pulmonary host defenses to pathogens such as M. tuberculosis and HIV-I. 2. To assume an active role in career development by training and assisting trainees in securing funding either for additional postdoctoral training or for faculty development depending on their level of training at entree into the program and development in the training program.