ATTENTIONAL PROCESSING OF TEMPORAL INFORMATION

描述(由申请人提供)：基本行为过程，如 联想学习、费率计算和决策关键依赖于 秒到分钟范围内的时间间隔的估计和再现 (间隔计时)。大多数时机理论的基本假设之一是 受试者能够容易地从输入刺激中提取时间 信息，并根据这个提示调整他们的行为，而不管 实际计时事件的非时态属性。相比之下，有证据表明 动物和人类的计时都高度敏感于 因此，定时信号支持“注意开关/门”的概念 间隔计时机构。 本研究的目的是研究时间的注意加工。 在秒到分钟范围内的信息(间隔计时) 多层次、行为学、神经药理学和计算方法。 在行为上，研究人员将研究一种新开发的间隔计时 对时间线索进行注意处理的过程。在这个范围内 程序中，调查员建议评估 计时的刺激特征和计时的记忆。从药理上讲， 研究人员建议将时钟效应和注意力分离 特异性多巴胺激动剂和拮抗剂对间期计时的影响。我们 也建议研究与注意有关的神经底物。 定时的开关/门机构。在计算上，调查员建议 建立了时间间隔的注意开关/门机制模型 为了解决行为和药物操纵对 对时间信息的注意处理。 这些研究将为当前的模型提供关于时间、时间感知和 间隔计时的神经药理学。它们将提供新的手段 理解注意因素对复杂认知机制的影响 这需要时间处理。它们将有助于阐明药理作用 时间信息注意加工的神经基础

DESCRIPTION (provided by applicant): Fundamental behavioral processes such as associative learning, rate calculation and decision making crucially rely on estimation and reproduction of time intervals in the seconds-to-minutes range (interval timing). One of the underlying assumptions of most timing theories is that subjects are able to readily abstract from the input stimulus the temporal information, and to tune their behavior according to this cue, irrespective of non-temporal properties the real timed event. In contrast, evidence suggests that both animal and human timing is highly sensitive to properties of the timed signal thus supporting the notion of an "attentional switch/gate" interval timing mechanism. The objective of this proposal is to study attentional processing of temporal information in the seconds-to-minutes range (interval timing) using a multi-level, behavioral, neuropharmacological, and computational approach. Behaviorally, the investigator will study a newly developed interval timing procedure shown to engage attentional processing of temporal cues. Within this procedure, the investigator proposes to evaluate the impact of the characteristics of stimuli on timing and memory for timing. Pharmacologically, the investigator proposes to dissociate the clock effects and attentional effects of specific dopamine agonists and antagonists on interval timing. We also propose to investigate the neural substrates involved in the attentional switch/gate mechanism of timing. Computationally, the investigator proposes to develop a model of the attentional switch/gate mechanism of interval timing in order to address the effect of behavioral and pharmacological manipulations on attentional processing of temporal information. The studies will inform current models of timing, time perception, and neuropharmacology of interval timing. They will provide new means for understanding the impact of attentional factors on complex cognitive mechanisms that require temporal processing. They will help elucidate the pharmacological and neural basis of attentional processing of temporal information