SEX-RELATED DETERMINANTS OF PAIN RESPONSES IN FIBROMYALGIA-FAMILY STUDY

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。本研究的总体目的是为了更好地了解纤维肌痛（FM）的两个标志性特征，即，与男性相比，女性患这种疾病的频率更高，以及FM患者表现出的疼痛敏感性异常。因此，我们将测试关于这些问题的7个假设，这些假设来自于由本应用程序的主要研究者开发的FM的发病模型。为了实现我们的总体目标，将从6组研究参与者中获得疼痛敏感性、血清血清素水平以及基因组DNA的数据。这些组包括：(1)女性FM患者80例（先生）；(2) FM患者男性兄弟姐妹40例；(3) FM患者女性兄弟姐妹40例；(4)女性健康对照（无fm） 80例；(5)对照组男性兄弟姐妹40名；(6)对照组女性兄弟姐妹40名。实证支持我们的假设将提供第一个证据：(a) FM家族史与多种疼痛敏感性测量的异常反应和相对较低的血清血清素水平有关；(b)这些异常的疼痛反应和血清素水平主要发生在FM女性的女性家庭成员中。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The overall aim of this investigation is to better understand two of the hallmark features of fibromyalgia (FM), i.e., the higher frequency of this disorder among women relative to men and the abnormalities in pain sensitivity shown by persons with FM. Therefore, we will test 7 hypotheses regarding these issues that are derived from an etiopathogenetic model of FM developed by the primary investigators of this application. In order to achieve our overall aim, data on pain sensitivity and blood serum levels of serotonin, as well as genomic DNA, will be obtained from 6 groups of study participants. These groups include: (1) 80 female FM patients (probands); (2) 40 male siblings of the FM patients; (3) 40 female siblings of the FM patients; (4) 80 female, healthy control (FM-free) subjects; (5) 40 male siblings of the control subjects; and (6) 40 female siblings of the control subjects. Empirical support for our hypotheses will provide the first evidence that (a) family history of FM is associated with abnormal responses on multiple measures of pain sensitivity and relatively low blood serum levels of serotonin; and (b) these abnormal pain responses and serotonin levels occur predominantly in the female family members of women with FM.