Novel laser architectures for the next generation of multi-photon imaging tools

自上世纪90年代末S首次展示这一技术以来，多光子成像技术已经彻底改变了生命科学的许多领域。激光技术的进步使这项技术的能力得到了提高，大型复杂激光系统被小型低成本解决方案所取代，转移到临床应用也指日可待。这个项目的目标是开发简单、低成本的激光结构，使其能够获得更高的峰值功率、新的激光波长和可伸缩的脉冲能量。目前的学术研究表明了一些有趣的技术，但这些想法必须经过测试和开发才能评估工业应用的适用性。以现有的相关技术为基础，项目目标将是设计解决方案、数值建模和构建性能演示系统，以便在产品开发中就最佳技术推向市场做出决策。这些解决方案将在性能和成本方面将现有技术推向最先进的水平。与该项目相关的新颖性、规模和挑战将导致可能的IP产生、发布合适的结果和适合商业化的技术解决方案的结果，以增加当前的市场份额和打开新的市场机会。新颖性在于设计和销售一种提供新波长和比市场上其他激光源更高的功率/能量的激光系统的最终工业挑战。这一挑战很可能将允许构建一种性能优于学术出版物最先进水平的激光系统。

Multi-photon imaging has revolutionised many fields of life-science since the process was first demonstrated in the late '90's. Advances in laser technology have enabled improvement in the capabilities of this technique, with large complex laser systems being replaced by small low cost solutions and with the migration to clinical applications now within reach. The development of simple low-cost laser architectures that will give access to higher peak power, new laser wavelengths and scalable pulse energies is the goal of this project. Current academic research indicates some interesting technologies, but these ideas must be tested and developed to assess applicability for industrial use.Taking some existing Coherent technology as a base, the project goal will be to design solutions, numerically model, and construct performance demonstration systems to allow decisions to be made about the best technology to bring to market in a product development. These solutions will push existing technology beyond current state of the art for both performance and cost. The novelty, scale and challenge associated with the project will result in likely IP generation, publication suitable results and the outcome of a technical solution suitable for commercialisation increasing current market share and opening new market opportunities.The novelty is in the ultimate industrial challenge of designing and selling a laser system that offers new wavelengths and with higher power/ energy than other laser sources available on the market. It is likely this challenge will allow the construction of a laser system with performance that improves upon the state of the art from academic publications.