Functional characterisation of novel metabolites in asthma and identification of new biomarkers

哮喘是一种呼吸道慢性炎症性疾病，是一种主要的健康负担。严重哮喘患者占该病患者的10%，由于病情加重和对现有治疗方法的耐药性，严重哮喘已成为一个紧迫的问题。我们首次对严重哮喘患者气道中代谢物的改变进行了研究，并确定了功能性代谢物和疾病生物标志物。我们现在的目标是评估这些分子在哮喘疾病模型中的功能。

Asthma is a chronic inflammatory disease of the airways that represents a major health burden. Severe asthma represents 10% of those suffering the disease and poses an urgent problem due to exacerbations and resistance to current therapies. We have conducted the first study of the metabolites that are altered in the airways of patients with severe asthma and identified functional metabolites and disease biomarkers. We now aim to assess the function of these molecules in asthma disease models.