Functional characterisation of novel metabolites in asthma and identification of new biomarkers

哮喘是一种气道慢性炎症性疾病，是一个主要的健康负担。严重哮喘占疾病患者的10%，并且由于加重和对当前疗法的抵抗而构成紧急问题。我们进行了第一项研究，研究了严重哮喘患者气道中改变的代谢物，并确定了功能性代谢物和疾病生物标志物。我们现在的目标是评估这些分子在哮喘疾病模型中的功能。

Asthma is a chronic inflammatory disease of the airways that represents a major health burden. Severe asthma represents 10% of those suffering the disease and poses an urgent problem due to exacerbations and resistance to current therapies. We have conducted the first study of the metabolites that are altered in the airways of patients with severe asthma and identified functional metabolites and disease biomarkers. We now aim to assess the function of these molecules in asthma disease models.