Scope and Causes of Stillbirth

描述（由申请人提供）：加尔维斯顿德克萨斯大学医学分部（UTMB）有能力作为NIH多站点死产网络的成员积极参与。PI George R. Saade，医学博士，在几个NIH多站点临床试验og中提供丰富的经验：妊娠早期和中期非整倍体风险评估（FASTER）；孕早期颈部不透明与先天性心脏病的风险双胎输血综合征试验；产前硫酸镁研究（BEAM）的有益效果。我们通过经常参与UTMB广泛的区域妇幼保健计划（RMCHP），成功地招募和保留了患者。所有RMCHP的诊所都遵循母胎医学部门制定的协议，患者在加尔维斯顿的UTMB分娩。由UTMB服务的两个县（加尔维斯顿和布拉索利亚）的孕妇将构成基于地理的人口。其中90%以上的患者在UTMB诊所接受治疗，并在约翰·西利医院分娩。如有需要，可酌情将目标人群扩展到基于邮政编码或县的其他RMCHP诊所。此外，该部的电子医疗记录记录了产前和分娩时的信息，并联机输入，授权调查人员可以随时查询。以同样的方式，我们部门的组织库为临床研究增加了广泛的效率。PI和Co-I， Radec Bukowski， MD， PhD之间的出色和富有成效的合作为死产网络提供了进一步的好处。此外，我们部门的遗传学咨询师Jennifer Lee将担任我们网站的外联工作人员，作为一名成熟的悲伤咨询师，她带来了丰富的经验。我科拥有一支富有成效和资金充足的基础科学研究团队，在感染、血管生理学、胎盘功能和胎儿生长等与RFA相关的许多领域拥有专业知识。最后，我们与我校病理科、遗传学和新生儿科建立了良好的合作关系（见支持信）。特别值得一提的是，UTMB拥有一个备受推崇的围产期病理学部门，在该RFA感兴趣的各个领域拥有专业知识，包括神经病理学和胎盘病理学。根据我们目前对DNA微阵列技术的兴趣，我们提出的研究概念是确定死产特有的单核苷酸多态性（SNP）标记谱。我们接受本RFA的出资和参与规定，并随时准备成为NIH死产网络的贡献成员。

DESCRIPTION (provided by applicant): The University of Texas Medical Branch at Galveston (UTMB) has the capability to participate actively as a member of the NIH multisite Stillbirth Network. PI George R. Saade, MD, offers extensive experience within several NIH multisite clinical trials og: First and Second Trimester Evaluation of Risk of Aneuploidy (FASTER); First Trimester Nuchal Translucency and the Risk of Congenital Heart Disease; Twin-Twin Transfusion Syndrome Trial; and Beneficial Effects of Antenatal Magnesium Sulfate Study (BEAM). We have achieved successful patient recruitment and retention by frequent involvement with UTMB's extensive Regional Maternal & Child Health Program (RMCHP). All of RMCHP's clinics follow protocols established by the Maternal-Fetal Medicine division, and the patients are delivered at UTMB in Galveston. Pregnant women in two counties served by UTMB--Galveston and Brazoria--will constitute the geographic-based population. More than 90% of these patients are cared for at a UTMB clinic and deliver at John Sealy Hospital. If needed, this target population can be expanded to other RMCHP clinics based on zip codes or counties, as appropriate. Further, the Department's Electronic Medical Record captures antepartum and intrapartum information, entered on-line, that is readily available for query by authorized investigators. In like manner, our Department's Tissue Bank has added broad efficiencies to clinical investigation. The excellent and productive collaboration between PI and Co-I, Radec Bukowski, MD, PhD, offers further benefits to the Stillbirth Network. In addition, our Department's genetics counselor, Jennifer Lee, who will serve as our site's outreach worker, brings considerable experience as an established grief counselor. Our Department has a very productive and well-funded basic science research group with expertise in many areas of relevance to the RFA, such as infection, vascular physiology, placental function, and fetal growth. Finally, we have well-established collaborative ties with our University's Department of Pathology and divisions of Genetics and Neonatology (see letters of support). In particular, UTMB has a highly regarded Perinatal Pathology division with expertise in various areas of interest to this RFA, including neuropathology and placental pathology. Following on our current interest in DNA microarray technology, our proposed study concept is to determine a single nucleotide polymorphism (SNP) marker profile particular to stillbirth. We accept the capitation and participatory stipulations of this RFA and stand ready to become a contributinq member of the NIH Stillbirth Network.