Pediatric Physician Scientists in Translational Molecul*

描述(申请人提供)：为了更多地将基础科学研究中的知识转化为临床应用，从而改善儿童的健康，我们建议在儿科系内设立一个儿童炉研究中心。CHRCDA的主要重点将是在儿童疾病的分子生物学方面培训年轻的儿科医生，重点是将他们的实验结果转化为改善儿童保健。CHRCDA将专注于生物医学研究的四个领域：(1)遗传学和发育生物学，(2)与肺损伤有关的肺部疾病，(3)造血系统疾病，以及(4)传染病，包括使用微生物作为基因传递的载体。我们利用前CHRCDA提供的资源，成功地培训了独立的儿科研究人员，并提供了一批经验丰富的CRHC导师以及来自UAB和儿科的机构支持。在这项应用中，我们将在以前经验的基础上，修改我们的培训计划，包括当代临床研究的密集研究，以及正式介绍使用基因组和蛋白质技术以及生物信息系统的实验方法。我们的目标是通过研究技术和方法的基础来增强指导下的研究经验。我们相信，这一培训计划将培养出最具竞争力的年轻研究人员，并促进独立研究事业的发展。

DESCRIPTION (provided by applicant): In order to increase the transfer of knowledge from basic science studies into clinical applications that will improve the health of children, we propose to maintain a Child Hearth Research Center within the Department of Pediatrics. The major focus of the CHRCDA will be to train young pediatricians in the molecular biology of diseases of childhood with an emphasis on translating their experimental findings into improved healthcare for children. The CHRCDA will focus on four areas of biomedical research: (1) genetics and developmental biology, (2) pulmonary diseases associated with lung injury, (3) diseases of the hematopoietic system, and (4) infectious diseases, including the use of microbes as vectors of gene delivery. We have successfully trained independent pediatric investigators utilizing the resources provided by the previous CHRCDA and offer an outstanding group of experienced CRHC mentors and the institutional support from UAB and the Department of Pediatrics. In this application, we will build on our previous experience and modify our training program to include intensive studies in contemporary clinical research as well as formal introductions to experimental approaches employing genomic and proteomic technologies and bioinformatic systems. Our goal is to enhance the mentored research experience with a foundation of research techniques and approaches. We believe that this training program will produce the most competitive young investigators and foster the development of independent research careers.