Fungal determinants and host cell death signals in fatal Candida infections
Fungal determinants and host cell death signals in fatal Candida infections
批准号:
nhmrc : 1081072
负责人:
A/Pr Ana Traven
金额:
$43.61万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2015
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2015-01-01 至 2017-12-31
中文摘要
真菌病原体是医院环境中的一个主要负担,因为它们逃避免疫系统并导致致命的败血症。本项目将确定真菌病原体念珠菌用来杀死宿主免疫细胞的分子因子。我们将研究免疫细胞死亡是否导致高致死率(通常与全身性念珠菌感染相关),以及新的治疗方法是否可以针对这一点。
英文摘要
Fungal pathogens are a major burden in hospital settings as they evade the immune system and cause lethal sepsis. This project will determine the molecular factors utilized by the fungal pathogen Candida to kill host immune cells. We will investigate whether immune cell death contributes to the high fatality rate, commonly associated with systemic Candida infections, and whether this can be targeted by novel therapeutics.
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海外基金