Implantable Glucose Sensor with Prolonged Accuracy

描述(申请人提供)：这项研究的目标是制造一种能够在体内准确工作3天的血管内血糖传感器。为此，我们将开发一种外膜，促进内源性S-亚硝硫醇在膜/血液界面局部转化为一氧化氮。由于一氧化氮是由内皮细胞释放的，负责维持血管张力和血小板失活，这是一种模仿内皮功能的自然方法。本研究包括生物相容性葡萄糖选择性膜的设计，功能性葡萄糖传感器的制作，以及用于评估该传感器的生物相容性和功能的台架和动物试验。持续监测血糖水平一直是一个难以实现的目标，但在管理胰岛素治疗方面将极大地改善危重患者的护理。

DESCRIPTION (provided by applicant): The goal in this study is to fabricate an intravascular glucose sensor that functions accurately for 3 days in vivo. To do this, we will develop an outer membrane that facilitates the conversion of endogenous S- nitrosothiols to nitric oxide locally at the membrane/blood interface. Since nitric oxide is released by the endothelial cells and is responsible for maintaining vascular tone and platelet inactivation, this is a natural approach that mimics the functions of the endothelium. This study involves the design of a biocompatible glucose-selective membrane, fabrication of a functional glucose sensor, and bench and animal testing to assess biocompatibility and function of the sensor. Continuous monitoring of blood glucose levels has been an elusive goal, but would greatly improve the care for critically ill patients in managing insulin therapy.