INDUCTION OF PLASMODIUM INFECTIONS TO SUPPORT MALARIA VACCINE STUDIES

本子项目是利用由NIH/NCRR资助的中心赠款提供的资源的众多研究子项目之一。子项目和研究者（PI）可能已经从另一个NIH来源获得了主要资金，因此可以在其他CRISP条目中表示。列出的机构是中心的，不一定是研究者的机构。在黑猩猩中诱导短期感染以获得用于基因工程研究的血期寄生虫，提取抗原用于血清学试验，通过膜喂养感染蚊子以产生用于基因工程研究的感染蚊子，生产用于血清学试验的单克隆抗体和孢子虫抗原，以测试传播阻断和抗孢子虫疫苗的功效，以及生产免疫血清。在这一年中，有3只黑猩猩感染了卵形疟原虫；从这些动物身上收集血液，然后用于这些研究或冷冻以备将来的研究。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Short-term infections were induced in chimpanzees to obtain blood-stage parasites for genetic engineering studies, the extraction of antigen for serologic tests and the infection of mosquitoes through membrane feeding to produce infected mosquitoes for genetic engineering studies, production of monoclonal antibodies, sporozoite antigens for serologic testing, to test the efficacy of transmission-blocking and anti-sporozoite vaccines, and the production of immune sera. During the year 3 chimpanzees were infected with Plasmodium ovale; from these animals blood was collected and then used for these studies or frozen for future studies.