COBRE KS: XRAY CRYSTALLOGRAPHY CORE (JULY 1-DECEMBER 31, 2004)

描述(由申请人提供)：申请五年的支持 创建教师发展计划，使初级教师能够参与 在堪萨斯州的三个博士授予机构的研究中，(KU at Lawrence 以及堪萨斯城的KU医学院和K州立大学) 在获得NIH拨款支持方面变得更具竞争力。这将会实现的 通过创建一个强大的指导机构(由Narayan博士和其他人组成 由美国国立卫生研究院资助的这三个机构的资深教员)， 设立科布雷内部和外部顾问委员会 每月研讨会和数据报告的程序化、制度化 会议，以及专门讨论筹备工作重要因素的年度会议 国家卫生研究院的拨款申请。三个核心、一个管理核心和两个技术核心 将建立以加快研究计划。科布雷将收到 以FTE、新的研究设备、 和空间。研究主题围绕抑制机制展开。 病原微生物的复制，长期目标是控制 传染病对人类健康很重要。研究的重点将放在 鉴定具有种子作用的基因和基因产品 微生物复制。为了找到这些蛋白质的抑制剂，我们将把 在科罗拉多大学劳伦斯分校利用科布雷计划开发组合资源 蛋白质抑制剂的化学和高通量筛选 问题。我们还将利用核心支持来开发更多的生物学方法 利用噬菌体展示和适体技术，将在 调查人员。此外，我们将在X光领域建立核心设施 结晶学和发酵法用于分离和测定 蛋白质的三维结构，这将有助于开发 潜在的毒品。六名初级教职员工，其中两名经验丰富 X射线结晶学家，已经被选为支持两到三个 好几年了。目前被选中的教员的项目是基于科学的 优点、与其他项目互补互动的潜力，以及 开发两个Cobre计划的核心资源的潜力。项目 将选出新的初级教员，并根据以下推荐颁发奖项 内部咨询委员会。科布雷基金的一部分将用于 加强教师招聘方案。

DESCRIPTION (provided by applicant): Five years of support are requested to create a faculty development program that will enable junior faculty involved in research at the three PhD granting institutions in Kansas, (KU at Lawrence and the KU School of Medicine in Kansas City, and K State University) to become more competitive for securing NIH grant support. This will be achieved by creation of a strong mentoring body (comprised of Dr. Narayan and other established, NIH-funded senior faculty at the three institutions), establishment of committees of internal and outside advisors to the COBRE program, institutionalization of monthly seminar and data presentation meetings, and an annual meeting dedicated to factors important in preparation of NIH grant applications. Three cores, one administrative, and two technical will be established to expedite the research program. The COBRE will receive extensive institutional support in the form of FTEs, new research equipment, and space. The research theme is centered on mechanisms inhibiting replication of pathogenic microbes, with the long-term goal of controlling infectious diseases important in human health. Studies will be focused on identification of genes and gene products that have a seminal role in microbial replication. To find inhibitors for these proteins, we will link up with the COBRE program at KU/Lawrence to exploit resources in combinatorial chemistry and high-throughput screens for inhibitors of the proteins in question. We will also exploit more biological approaches using core support with phage display and aptamer technology, which will be shared among investigators. Further, we will establish core facilities in X-ray crystallography and fermentation for the isolation and determination of the 3-D structures of the proteins, which will be useful for development of potential drugs. Six junior faculty members, two of whom are experienced X-ray crystallographers, have been selected for support for two to three years. The projects of currently selected faculty were based on scientific merit, potential for complementary interaction with other projects, and potential for exploiting the core resources of both COBRE programs. Projects of new junior faculty will be selected and awards made upon recommendation of the internal advisory committee. A portion of the COBRE fund will be used to enhance faculty recruitment packages.