Functional Genome/Proteomic--Pathogen-Host Interactions

描述(由申请人提供)： 这位科布雷利用了近年来俄克拉荷马州走在前列的为数不多的生物医学研究领域之一，即细菌发病机制的基因组规模分析。我们建议建立一个以细菌-宿主相互作用的功能基因组/蛋白质组分析为主题的COBRE。四名初级调查人员在三个主要的州立大学校园得到了资助。我们取得了惊人的成功率。所有这些人后来都得到了NIH同行评审的资金，并轮流获得了这笔赠款。他们的成功使我们能够资助另外四名研究人员，他们正在完成他们的研究项目的不同阶段。最初的Cobre是按照典型的计划项目赠款的结构设计的，但专注于俄克拉荷马州年轻的、发展中的科学家。从第2年到第5年，我们已经进化了赠款的结构和操作，以跟上原始RFA的后续迭代的变化(RR-00-003)。这包括最多三年的资助、毕业程序、导师更有条理的角色、纳入4个初级项目和2个为期一年的试点项目。这个应用程序继续了主旋律，更直接地关注蛋白质组学。为了支持这一目标，我们正在建立一个蛋白质组学核心实验室，我们正在招聘一名蛋白质组学磁铁研究员。对这一职位的机构支持包括一个专门赚取终身教职的职位和一个由机构资助的增强启动一揽子计划。我们还在第2-5年预留了资金，以帮助与这项科布雷和俄克拉何马州INBRE赠款有关的所有俄克拉何马州机构招聘人员，以吸引与研究主题一致的调查人员。此外，与校园内另外两个科布雷助学金的私人投资项目相关联，我们正在举办联合研究务虚会和会议，以增加我们资助的研究人员进行跨学科研究的机会。科布雷由一位由NIH资助的知名调查人员领导，他与INBRE-PI一起领导了一项全州范围的倡议，该倡议包括俄克拉何马州三家主要的公共支持的研究机构和12家机构的网络，其中包括俄克拉何马州唯一的历史上唯一的黑人大学、全美原住民人数最多的本科院校、俄克拉何马州唯一的部落学院和其他几所拥有大量来自代表不足的群体的学生的机构。

DESCRIPTION (provided by applicant): This COBRE has exploited one of the few areas of biomedical research where Oklahoma has been in the forefront in recent years, which is the genome-scale analysis of bacterial pathogenesis. We proposed to establish a COBRE, with the thematic focus of Functional Genomic/Proteomic Analysis of Bacterial-Host Interactions. Four junior investigators were funded on the three main state university campuses. We achieved a phenomenal success rate. All these individuals have subsequently received peer-reviewed NIH funding and rotated off the grant. Their successes have allowed us to fund an additional four investigators who in are various stages of completion of their research projects. The original COBRE was structured as a typical Program Project Grant, but focused on young, developing scientists in the state of Oklahoma. From years 2 -5 we have evolved the structure and operation of the grant to keep pace with changes in subsequent iterations of the original RFA (RR-00-003). This included a maximum of three years of funding, graduation procedures, more structured roles for mentors, inclusion 4 junior projects and 2 one-year pilot projects. This application continues the main theme with a more directed focus into proteomics. To support this goal, we are establishing a proteomics core laboratory and we are recruiting a proteomics magnet investigator. Institutional support for this position includes a dedicated tenure-earning position and a institutionally funded start-up package enhancement. We also have reserved funds in years 2-5 to assist all Oklahoma institutions associated with this COBRE and the Oklahoma INBRE grant in recruitment efforts to attract investigators who are consistent with the research theme. Further, in association with the PIs of the two other COBRE grants on campus, we are instituting joint research retreats and meetings to enhance interdisciplinary research opportunities among our funded investigators. The COBRE is headed by an established NIH-funded investigator who leads a state-wide initiative along with the INBRE-PI that includes the three major publicly-supported research institutions in the state of Oklahoma and a network of 12 institutions including Oklahoma's only historically black university, an undergraduate institution with the highest number of native Americans of any college in the nation, Oklahoma's only tribal college and several other institutions with large numbers of students from under-represented groups.