PESTICIDE-INDUCED DIFFERENTIATION AND HETEROGENEITY IN BREAST CANCER CELLS

描述(由申请人提供)：CVM-MSU内的环境健康科学中心(CEHS)提交了一份申请，要求开发一个以环境健康为总体科学主题，并特别强调杀虫剂的毒理影响的COBRE。我们的COBRE将是一个多学科的研究努力，有两个首要目标：1)发展初级教师个人的专业知识和可信度，使每个人都被公认为环境健康科学家社区中成功的、完全有权的成员，拥有来自同行审查机制(主要是R01资助)的独立、竞争性的资金支持；2)培养一支能够竞争项目研究支持的科学家团队，以调查由农业化学品引起的环境健康问题。在组织上，行政核心将协调COBRE的总体活动，负责指导初级科学家的职业发展，以提高他们的竞争力，并负责数据管理活动(数据录入和统计指导)。四个生物医学机制研究项目将基于假设驱动的研究，研究杀虫剂在不同发育阶段(从早期发育到衰老)对哺乳动物神经或内分泌系统的潜在影响。杀虫剂的毒性机制将在动物模型(包括传统的实验室啮齿动物和新的动物模型)中进行研究。研究资源核心将通过动物资源(动物子核)和共享仪器(成像子核和分析化学子核)为这些生物医学项目提供基础设施。此外，流行病学和暴露评估项目将为正在研究的生化和生理机制带来现实世界的视角。将对实验室空间进行翻新。科学项目的首席调查人员(PI)是初级教员，他们展示了不同但互补的专业知识领域，所有这些人都可以单独和有计划地回答在评估杀虫剂对选定的人类健康领域的影响方面的关键问题。所有这些机构都致力于开发在环境健康领域有用的科学问题或方法方面的新的或扩展的专业知识，这些专业知识适合国家环境健康科学研究所(NIEHS)的优先研究领域，我们希望最终能争取到该研究所的支持。

DESCRIPTION (provided by applicant): The Center for Environmental Health Sciences (CEHS) within the CVM-MSU submits an application to develop a COBRE with the overall scientific theme of environmental health, and a specific emphasis on the toxicological effects of pesticides. Our COBRE would be a multi-disciplinary research effort with two overarching goals: 1) to develop individual junior faculty expertise and credibility so that each is recognized as a successful, fully enfranchised member of the community of environmental health scientists with independent, competitive funding support from peer-reviewed mechanisms (primarily R01 grants); and 2) to develop a team of scientists who can compete for programmatic research support, such as a program project grant, for investigation of environmental health problems elicited by agricultural chemicals. Organizationally, an Administrative Core would coordinate overall activities of the COBRE, and be responsible for mentoring the junior scientists in their career development to increase their competitiveness, and for data management activities (data entry and statistical guidance). Four biomedical mechanistic research projects will be based on hypothesis-driven studies of the potential effects of pesticides on the mammalian nervous or endocrine systems at various stages of development (from early development through aging). The mechanisms of toxicity of pesticides will be investigated in animal models (both traditional laboratory rodents as well as new animal models). A Research Resources Core would provide infrastructure to these biomedical projects through animal resources; (Animal Sub-Core) and shared instrumentation (Imaging Sub-Core and Analytical Chemistry Sub-Core). In addition, an epidemiology and exposure assessment project would bring real world perspectives to the biochemical and physiological mechanisms under study. Renovation of laboratory space would occur. The Principal Investigators (PI) of the science projects are junior faculty who demonstrate distinct but complementary areas of expertise, all of whom can contribute individually and programmatically to answering critical questions in the assessment of the impact of pesticides on selected areas of human health. All are committed to developing new or expanded expertise in scientific questions or methodologies useful in the area of environmental health, and that fit the priority research areas of the National Institute of Environmental Health Sciences (NIEHS), for whose support we hope to ultimately compete.