AR CAREER DEVELOPMENT COBRE: EXPERIMENTAL CORE

描述（由申请人提供）： 我们将为五名接近国家竞争水平的项目主要研究者（PI）实施职业发展计划，使用由既定研究者进行的赠款支持和指导活动。每个项目都涉及独特的，创新的最先进的研究。我们的目标是帮助这些PI在1-3年内获得指导性赠款或R 01资金，用接近国家竞争水平的其他调查人员取代他们，并帮助这些调查人员获得校外支持。在奖励期结束时，我们的目标是1）为至少七名新调查员提供指导赠款和R 01资金，2）确保另外两名多名调查员获奖。所选择的项目具有显著的协同作用，这将有助于实现第三个目标，3）提交一份计划项目申请（P01），将至少三名新的R 01获奖者与其他已建立的研究人员联系起来。我们还将建立一个多学科的转化神经科学中心（CTN），该中心将利用现有的师资力量，扩大神经科学研究基础设施，成为全校合作的中心。CTN还将受益于招聘两名终身制、中高级、受资助的调查员，他们也将成为项目PI的导师。此外，在该奖项的有效期内，还将招募另外三名初级教员，以增加调查人员的临界质量。其他潜在的未来PI将通过试点研究奖励计划招募。这一努力的重大机构承诺，将在奖励期结束时转化为对中心的独立校外支持（P50奖）。CTN的主任拥有大规模发展计划，计划项目赠款的经验，并已获得联邦资助超过20年。我们将建立一个核心设施和一个实验核心，以提供一种有效的手段，确保由训练有素的专业人员充分利用、维护和操作复杂而昂贵的仪器。我们将确保项目PI能够获得最先进的服务和设施（通过每年购买新设备），为UAMS的转化神经科学研究工作提供基本支持。

DESCRIPTION (provided by applicant): We will implement a Career Development Program for five Project Principal Investigators (PIs) who are close to nationally competitive levels using grant support and mentoring activities undertaken by established investigators. Each Project involves unique, innovative state-of-the-art research. The goal is to help these PIs secure mentored grants or R01 funding within 1-3 years, replacing them with other investigators close to nationally competitive levels, and helping those investigators secure extramural support. By the end of the award period, our goals are 1) to generate mentored grants and R01 funding for at least seven new investigators, and 2) to secure two additional multi-investigator awards. The Projects chosen have significant synergy, which will facilitate the third goal, 3) the submission of a Program Project application (P01) linking at least three of the new R01 awardees with other established investigators. We will also establish a multi-disciplinary Center for Translational Neuroscience (CTN) that will take advantage of the existing faculty strengths and expand the neuroscience research infrastructure, becoming a hub for campuswide collaborations. The CTN will also benefit from the recruitment of two tenure-track, mid- to senior-level, funded investigators who will also become mentors to Project PIs. In addition, three other faculty of junior rank will be recruited during the life of the award, adding to the critical mass of investigators. Additional potential future PIs will be recruited through a Pilot Study award program. The significant institutional commitment for this effort, will be parlayed into independent extramural support for the Center (P50 award) by the end of the award period. The Director of the CTN has experience with large-scale development programs, Program Project grants and has been Federally funded for over 20 years. We will establish a Core Facility and an Experimental Core, to provide an efficient means of ensuring that sophisticated and expensive instrumentation is fully utilized, maintained and operated by trained professionals. We will ensure that Project PIs have access to state-of-the-art services and facilities (through yearly purchases of new equipment), providing the basic underpinnings of the translational neuroscience research efforts at UAMS.