CLAUDE D.PEPPER OLDER AMERICANS INDEPENDENCE CENTERS

描述(由申请人提供)：这是密歇根大学(UM Pepper Center)克劳德·D·佩珀老年美国人独立中心(OAIC)的竞争性续签申请。密歇根大学胡椒中心的具体目标是：1)支持侧重于通过改善对衰老表型的预测和调节因素及其导致的健康结果的理解来提高老年人独立性的研究。2)通过支持将老年人衰老和导致残疾的常见健康问题的基础和临床研究联系起来的转译研究，帮助维持和恢复老年人的独立性。3)提供研究资源核心(RRC)，以支持和协助研究人员发起的研究项目，这些项目可以导致对导致老年人衰老和丧失独立性的基本条件的基本机制有新的见解，以及核心开发项目，该项目开发和测试应用于该等研究项目的创新方法。4)通过其研究职业发展核心(RCDC)，加强UM环境，以培养未来老年学和老龄领域的学术带头人，他们可以对导致衰老表型的基本机制进行研究，可以开发新的方法来加强翻译研究，并可以对有希望的干预措施进行临床试验，以提高老年人的独立性。5)通过其试点和探索性研究核心(PESC)，吸引以前没有参与老龄化研究的密歇根大学初级教员和高级教员来研究易导致衰老表型的问题，并开展转化性研究，以保持和提高老年人的独立性。 密歇根州立大学胡椒中心建立了完善的领导和管理结构，包括区域疾病预防控制中心和PESC的关键要素，以及四个区域资源中心，所有这些都是在过去14年期间在密歇根大学胡椒中心的主持下组织和资助的。这些中心包括人类科目和评估核心(HSAC)、生物机械核心、方法学、数据管理和分析核心(MDMAC)和老年啮齿动物核心设施(CFAR)。在此应用中提出了一种新的基因组分析核心(GAC)。六个核心发展项目将加强这些区域资源中心的活动。RCDC有三个核心要素：1)具有竞争力的计划，以选择有前途的UM初级教员提供工资支持，以开展与UM Pepper中心研究重点相关的研究；2)针对从事此类研究的初级教员的研究培训计划；以及3)允许初级教员与一名或多名UM高级研究人员密切合作的导师计划。

DESCRIPTION (provided by applicant): This is a competing renewal application for support of the Claude D. Pepper Older Americans Independence Center (OAIC) at the University of Michigan (UM Pepper Center). The specific aims of the UM Pepper Center are: 1) To support research which has a focus on enhancing the independence of older adults by improved understanding of predictors and modulators of the aging phenotype, and its resulting health outcomes. 2) To help maintain and restore the independence of older people by supporting translational research linking basic and clinical research on aging and common health problems of older adults leading to disability. 3) To provide Research Resources Cores (RRCs) that support and assist investigator initiated research projects which can lead to new insights into the basic mechanisms underlying conditions that contribute to the aging phenotype and loss of independence of older adults, and Core Development Projects which develop and test innovative methods to apply to such research projects. 4) Through its Research Career Development Core (RCDC), to strengthen the UM environment for training of future academic leaders in geriatrics and aging who can conduct research on basic mechanisms contributing to the aging phenotype, can develop new methods to enhance translational research, and can carry out clinical trials of promising interventions to enhance independence of older adults. 5) Through its Pilot and Exploratory Studies Core (PESC), to attract UM junior faculty and senior faculty not previously involved in aging research to study problems predisposing to the aging phenotype and to carry out translational research to maintain and enhance independence of older adults. The UM Pepper Center has in place a well established leadership and administrative structure, the key elements of the RCDC and the PESC, and four RRCs, all of which were organized and funded under the auspices of the UM Pepper Center during the previous 14 years. These RRC's include the Human Subjects and Assessment Core (HSAC); the Biomechanies Core; the Methodology, Data Management and Analysis Core (MDMAC); and the Core Facility for Aged Rodents (CFAR). A new Genomic Analysis Core (GAC) is proposed in this application. Six Core Development Projects will strengthen the activities of theses RRCs. The RCDC features three central elements: 1) a competitive program to select promising UM junior faculty for salary support to conduct research relevant to the UM Pepper Center's research focus; 2) a research training program for junior faculty engaged in such research, and 3) a Mentorship Program that permits junior faculty members to work closely with one or more UM senior investigators.