Gene Expression Biomarkers Predict Severe Asthma Inflammatory Phenotype, Activation Mechanisms and Treatment Response

哮喘现在被认为是由几种疾病变种或表型组成的，这些变种或表型可能有不同的潜在原因和机制。我们缺乏对如何识别哮喘表型以及它们如何起作用的了解，这推迟了将导致治疗和患者护理改进的研究。对于患有严重疾病的人来说，这一点尤其重要。这笔赠款将建立一种基因测试来识别哮喘的表型，并进一步了解发病机制和治疗反应。

Asthma is now recognised to be made up of several disease variants or phenotypes, which are likely to have different underlying causes and mechanisms. We lack understanding of how to identify phenotypes of asthma and how they work, and this is delaying research that will lead to improvements in treatments and patient care. This is particularly important in people with severe disease. This grant will establish a gene test to identify asthma phenotype, and further understand mechanisms and treatment responses.