Clinical and Basic Neurobiology of Nervous System Diseases

描述（由申请人提供）：神经系统疾病造成的巨大残疾和痛苦负担，可以通过教育和让基础神经科学家参与疾病导向研究来最好地减轻。为了实现这一目标，我们计划为耶鲁大学的所有神经科学研究生开发一门关于“神经系统疾病的临床和基础神经生物学”的课程，并将其提供给全国各地的其他神经科学培训项目。该课程将是美国国立卫生研究院支持的“跨部门神经科学计划”（INP）（5T32 NS 41228，H。Keshishian PI）。新课程将是目前20个讲座课程“神经系统疾病的细胞和分子机制”的两倍多，重点是神经退行性疾病。这2门课程将包括总共44个讲座，涵盖神经病学，精神病学和儿童精神病学领域的各种疾病和障碍。除了讲座和书面教学大纲外，还将为44个讲座中的每个讲座创建教程，利用基于网络的交互式格式的文本，图形，数字，动画和视频剪辑，让学生回答问题并与数字或动画互动，生成即时反馈并提供指示掌握水平的总分。每个讲座教学大纲教程将包括疾病，流行病学，遗传学，病例介绍，临床过程，诊断方法，治疗，疾病的动物模型（重点是发病机制的特定和常见的神经生物学机制）的描述，以及转化研究的社会和伦理方面的讨论。该课程将由一个由2名共同原则研究者（临床科学家和INP的主要研究者）领导的执行咨询委员会指导，其他3名成员来自神经病学，精神病学和儿童医学系。 精神病学和教学人员将来自这三个组织。本课程将通过各种主观和客观的衡量标准进行评估，包括学生在教程中的得分。这门课程将在耶鲁大学之外产生影响，因为讲座的网络直播，教学大纲和教程将通过互联网提供给其他神经科学培训项目。相关性：神经系统疾病的神经生物学基础神经科学研究生的教育将促进他们参与以疾病为导向的研究，并导致改善预防和治疗。

DESCRIPTION (provided by applicant): The immense burden of disability and suffering produced by nervous system diseases can best be reduced by educating and involving basic neuroscientists in disease oriented research. To accomplish this we plan to develop a course on the "Clinical and Basic Neurobiology of Diseases of the Nervous System" for all neuroscience graduate students at Yale University and make it available to other neuroscience training programs across the country. The course will be part of the NIH supported "Interdepartmental Neuroscience Program" (INP) (5T32 NS 41228, H. Keshishian PI). The new course will more than double the current 20 lecture course "Cellular and Molecular Mechanisms of Neurologic Disease", which focuses on neurodegenerative diseases. The 2 courses will include a total of 44 lectures covering a wide range of diseases and disorders from the fields of Neurology, Psychiatry and Child Psychiatry. In addition to lectures and a written syllabus, tutorials will be created for each of the 44 lectures utilizing text, graphics, figures, animations and video clips in a web based interactive format to engage students in answering questions and interacting with figures or animations that generate immediate feedback and provide a total score indicating the level of mastery. Each lecture-syllabus-tutorial will include a description of the disease, epidemiology, genetics, case presentations, clinical course, diagnostic methods, treatment, animal models of disease (with a focus on both specific and common neurobiologic mechanisms of pathogenesis), and a discussion of social and ethical aspects of translational research. The course will be directed by an executive-advisory committee led by the 2 co-principle investigators - (a clinician scientist and the principal investigator of the INP) with 3 other members from the Departments of Neurology, Psychiatry and Child Psychiatry and teaching faculty will come from these same 3 organizations. The course will be evaluated with a variety of subjective and objective measures including student scores on the tutorials. The course will have an impact outside Yale University since a webcast of the lecture, the syllabus, and the tutorials will be made available via the internet to other Neuroscience Training Programs. Relevance: The education of basic neuroscience graduate students in the neurobiology of diseases of the nervous system will foster their involvement in disease-oriented research and lead to improved prevention and treatment.